Conference papers

2026

Bauvois, A., & Bosc, D. Kinetic Target-Guided Synthesis (KTGS): From Concept to MedChem Applications. 6èmes Journées du GDR ChemBio à Lille, Villeneuve d'Ascq, France, 4–5th June, 2026.

Nguyen, M.-N. T., Galizia, J., Ndjogou, D., Mendoza-Losana, A., Cole, S. T., Ramon-Garcia, S., Willand, N., Dubbelboer, I., & Simonsson, U. S. H. Modelling pharmacokinetic-pharmacodynamic of PBTZ-169 in glycerol and cholesterol using CFU and MPN as biomarkers 34th PAGE meeting, Dubrovnik, Croatia, 2–5th June,2026.

Hennequin, H., Desgardin, C., Carré, P., Chaibi, F.-Z., Novikov Gleb, Vatinel, R., Bou Karroum, N., Landry, V., Durand, C., Guez, S., Chiaravalli, J., Giraud, E., Biela, A., Piveteau, C., Leroux, F., Hanoulle, X., Agou, F., Deprez, B., & Charton, J. Multiparametric optimization of 3CLpro inhibitors delivered highly potent in vitro and in vivo anti SARS-CoV-2 compounds 39th International Conference on Antiviral Research (ICAR), Praha, CZ, Apr. 27th–May.1st,2026.

Vatinel, R., Sobieski, C., Compagne, N., Meurillon, V., Jiménez-Castellanos, J.-C., Lèbre, L., Piveteau, C., Dumont, J., Leroux, F., Deprez, B., Willand, N., Frangakis, A. S., Pos, K. M., Bonnet, R., Van Maele, L., Hartkoorn, R. C., & Flipo, M. Novel efflux pump inhibitors: tackling antimicrobial resistance in Enterobacterales Gordon Research Conference, New Antibacterial Discovery and Development, Lucca, Italy, 8–13th Mar.,2026.

Ruggieri, F., Warzee, A., Chatagnon, J., Djaout, K., Leroux, F., Dumont, J., Piveteau, C., Landry, V., Kaniecki, S., Chauffour, A., Fontaine, V., Sadowski, E., Aubry, A., Veziris, N., Hartkoorn, R. C., & Willand, N. Design and synthesis of nature-inspired libraries to discover new antitubercular agents Gordon Research Conference, New Antibacterial Discovery and Development, Lucca, Italy, 8–13th Mar.,2026.

Blanchart, P., Bou Karroum, N., Piveteau, C., Biela, A., & Deprez-Poulain, R. Design and implementation of kinetic target-guided synthesis for allosteric sites. 33rd Young Research Fellow Meeting SCT, Marseille, FR, 11th–13th Feb.,2026.

Louchet, T., Hasyeoui, M., Compagne, N., Binte-Zulkifli, N.-E., Sperandio, O., Chitnis, C., Deprez, B., Charton, J., & Willand, N. Design and synthesis of anti-malarial compounds targeting PRDX6 to combat the emergence of resistance. 33rd Young Research Fellow Meeting SCT, Marseille, FR, 11th–13th Feb.,2026.

Lucca, G., Vatinel, R., Sobieski, C., Lèbre, L., Deprez, B., Willand, N., C. Hartkoorn, R., & Flipo, M. Development of 6-substituted quinolines as efflux pump inhibitors to overcome antimicrobial resistance in Enterobacterales infections 33rd Young research Fellow Meeting SCT, Marseille, FR, 11th–13th Feb.,2026.

Bonnet, G., Bou Karroum, N., Descamps, F., Kraupner, N., Frazier, T., Dufossez, R., Gomez, V., Leclere, M., Hermant, P., Lebrun, S., Warenghem, S., Piveteau, C., Biela, A., Leroux, F., Deprez, B., Deprez-Poulain, R., & Bosc, D. In situ macrocyclisation to discover IDE inhibitors. 33rd Young Research Fellow Meeting SCT, Marseille, FR, 11th–13th Feb.,2026.

2025

Blanchart, P., Bou Karroum, N., Piveteau, C., Biela, A., & Deprez-Poulain, R. Design and implementation of kinetic target-guided synthesis for allosteric sites 10th Drug Discovery Day, Lille, FR, 12th Dec.,2025.

Bonnet, G., Bou Karroum, N., Descamps, F., Kraupner, N., Frazier, T., Dufossez, R., Gomez, V., Leclere, M., Hermant, P., Lebrun, S., Warenghem, S., Piveteau, C., Biela, A., Leroux, F., Deprez, B., Deprez-Poulain, R., & Bosc, D. KTGS to discover macrocylic IDE inhibitors 10th Drug Discovery Day, Lille, FR, 12th Dec,2025.

Louchet, T., Hasyeoui, M., Compagne, N., Binte-Zulkifli, N.-E., Sperandio, O., Chitnis, C., Deprez, B., Charton, J., & Willand, N. Design and synthesis of anti-malarial compounds targeting PRDX6 to combat the emergence of resistance 10th Drug Discovery day, Lille, FR, 12th Dec,2025.

Lucca, G., Vatinel, R., Sobieski, C., Lèbre, L., Deprez, B., Willand, N., Hartkoorn, R. C., & Flipo, M. Development of 6-substituted quinolines as efflux pump inhibitors to overcome antimicrobial resistance in Enterobacterales infections 10th Drug Discovery Day, Lille, FR, 12th dec.,2025.

Bonnet, G., Bou Karroum, N., Descamps, F., Kraupner, N., Frazier, T., Dufossez, R., Baheux, E., Gomez, V., Leclere, M., Hermant, P., Lebrun, S., Warenghem, S., Piveteau, C., Biela, A., Leroux, F., Deprez, B., Deprez-Poulain, R., & Bosc, D. Design and synthesis of 2 macrocycles as IDE inhibitors 59th International Conference on Medicinal Chemistry, RICT, Drug Discovery and Selection, Orleans, FR, 2nd-4th Jul.,2025.

Bou Karroum, N., He, B., Gealageas, R., Mauvais, F.-X., Warenghem, S., Roignant, M., Kraupner, N., Lam, B. V., Lesire, L., Couturier, C., Leroux, F., Van Endert, P., Deprez, B., & Deprez-Poulain, R. Discovery of novel and selective IRAP inhibitors 10th Scientific Meeting of the Institut Pasteur de Lille Lille, FR, 17th Jun.,2025.

Meurillon, V., Vieira Da Cruz, A., Compagne, N., Jiménez-Castellanos, J.-C., Deprez, B., Willand, N., Pos, K. M., Hartkoorn, R. C., & Flipo, M. Optimization of 6-substituted quinolines as novel class of Enterobacterale efflux pump inhibitors to fight antimicrobial resistance 10th Scientific Meeting of the Institut Pasteur de Lille Lille, FR, 17th Jun.,2025.

De Vasconcelos, F., Scaldaferri, V., Gragera, P., Król, K., Lesire, L., Herledan, A., Iatrou, H., Deprez-Poulain, R., & Fruci, D. Efficacy of novel potential ERAP inhibitors to enhance anticancer immunity CAPSTONE Open Conference : Targeting Antigen Processing in Autoimmunity and Cancer, INEM, Paris, France, 31st Mar.,2025.

Lesire, L., Herledan, A., Leroux, F., Couturier, C., Deprez, B., & Deprez-Poulain, R. High-throughput screening for discovering bioactive compounds that modulates antigen presentation CAPSTONE Open Conference : Targeting Antigen Processing in Autoimmunity and Cancer, INEM, Paris, France, 31st Mar.,2025.

Bou Karroum, N., He, B., Gealageas, R., Mauvais, F.-X., Warenghem, S., Roignant, M., Kraupner, N., Lam, B. V., Lesire, L., Couturier, C., Leroux, F., van Endert, P., Deprez, B., & Deprez-Poulain, R. Discovery of novel and selective IRAP inhibitors CAPSTONE Open Conference : Targeting Antigen Processing in Autoimmunity and Cancer, INEM, Paris, France, 31st Mar.,2025.

Fougiaxis, V., Barcherini, V., Petrovic, M., Sierocki, P., Warenghem, S., Leroux, F., Bou Karroum, N., Petit-Cancelier, F., Rodeschini, V., Roche, D., Deprez, B., & Deprez-Poulain, R. Discovery of new chemotypes as erap1-metalloprotease inhibitors through fragment-based screening CAPSTONE Open Conference : Targeting Antigen Processing in Autoimmunity and Cancer, INEM, Paris, France, 31st Mar. ,2025.

Bonnet, G., Dinh, C. P., Descamps, F., Kraupner, N., Deprez, B., Deprez-Poulain, R., & Bosc, D. Alkynes derived from α-amino acids: interests and synthesis 32nd Young Research Fellow Meeting SCT, Paris, FR, 26th-28th Feb.,2025.

Bou Karroum, N., He, B., Gealageas, R., Mauvais, F.-X., Warenghem, S., Roignant, M., Kraupner, N., Lam, B. V., Lesire, L., Couturier, C., Leroux, F., Van Endert, P., Deprez, B., & Deprez-Poulain, R. Discovery of novel and selective IRAP inhibitors 32nd Young Research Fellow Meeting SCT, Paris, FR, 26th-28th feb.,2025.

Meurillon, V., Vieira Da Cruz, A., Compagne, N., Jiménez-Castellanos, J.-C., Deprez, B., Willand, N., Pos, K. M., Hartkoorn, R. C., & Flipo, M. Optimization of 6-substituted quinolines as novel class of Enterobacterale efflux pump inhibitors to fight antimicrobial resistance 32nd Young Research Fellow Meeting SCT, Paris, FR,26th-28th Feb.,2025.

Fougiaxis, V., Barcherini, V., Petrovic, M., Sierocki, P., Warenghem, S., Leroux, F., Bou Karroum, N., Petit-Cancelier, F., Rodeschini, V., Roche, D., Deprez, B., & Deprez-Poulain, R. Discovery of novel chemotypes as ERAP1-metalloprotease inhibitors through fragment-based screening 32nd Young Research Fellow Meeting SCT, Paris, FR,26th-28th Feb.,2025.

2024

Descamps, F., Bou Karroum, N., Kraupner, N., Bonnet, G., Deprez-Poulain, R., Deprez, B. & Bosc, D. Design and synthesis of macrocyclic IDE modulators for therapeutic applications, 9th Drug Discovery Day, Lille, France, 13th Dec.,2024.

Fougiaxis, V., Barcherini, V., Petrovic, M., Sierocki, P., Warenghem, S., Leroux, F., Bou Karroum, N., Petit-Cancelier, F., Rodeschini, V., Roche, D., Deprez, B., & Deprez-Poulain, R. Discovery of novel chemotypes as ERAP1-metalloprotease inhibitors through fragment-based screening 9th Drug Discovery Day, Lille, France, 13th Dec.,2024.

Meurillon, V., Vieira Da Cruz, A., Compagne, N., Jiménez-Castellanos, J.-C., Deprez, B., Willand, N., Pos, K. M., Hartkoorn, R. C., & Flipo, M. Development of 6-substituted quinolines as novel class of Enterobacterale efflux pump inhibitors 9th Drug Discovery Day, Lille, France, 13th Dec.,2024.

Blanchart, P., Bou Karroum, N., Deprez, B., & Deprez-Poulain, R. Targeting dynamic allosteric sites of ERAP1 using KTGS strategy 9th Drug Discovery Day, Lille, France, 13th Dec.,2024.

Bou Karroum, N., He, B., Gealageas, R., Mauvais, F.-X., Warenghem, S., Roignant, M., Kraupner, N., Lam, B. V., Azaroual, N., Ultré, V., Rech, A., Lesire, L., Couturier, C., Leroux, F., Van Endert, P., Deprez, B., & Deprez-Poulain, R. Discovery of novel and selective IRAP inhibitors 9th Drug Discovery Day, Lille, France, 13th Dec.,2024.

Lesire, L., Herledan, A., Leroux, F., Couturier, C., Deprez, B., & Deprez-Poulain, R. High-throughput screening for discovering bioactive compounds that modulates antigen presentation ROSCOSCREEN 2024 : ETC2024 - Le criblage moléculaire pour la recherche de sondes chimiques d'intérêt en thérapie humaine., Roscoff, France, 24-27th Sept,2024.

Carre, P., Landry, V., Hennequin, H., Hanoulle, X., Charton, J., Deprez, B., & Leroux, F. Inhibition of 3CLpro enzymes of four coronaviruses : from High Throughput Screening to positive confirmation ROSCOSCREEN 2024 : ETC2024 - Le criblage moléculaire pour la recherche de sondes chimiques d'intérêt en thérapie humaine., Roscoff, France, 24-27th Sept,2024.

He, B., Warenghem, S., Leroux, F., Vatinel, R., Sierocki, P., Barcherini, V., Kraupner, N., Deprez, B., & Deprez-Poulain, R. Discovery of potent IRAP inhibitors using a combination of docking and SAR 31st SCT Young Research Fellows Meeting Grenoble, France, 22nd-23rd Feb,2024.

Descamps, F., Bou Karroum, N., Kraupner, N., Bonnet, G., Deprez, B., Deprez-Poulain, R., & Bosc, D. Design and synthesis of macrocyclic IDE modulators for therapeutic applications 31st SCT Young Research Fellows Meeting 22nd-23rd Feb,2024.

Bonnet, G., Bou Karroum, N., Kraupner, N., Descamps, F., Deprez, B., Deprez-Poulain, R., & Bosc, D. Towards macrocyclic IDE inhibitors: interests and synthesis 31st SCT Young Research Fellows Meeting Paris, France 22nd-23rd Feb,2024.

Fougiaxis, V., Barcherini, V., Petrovic, M., Sierocki, P., Warenghem, S., Leroux, F., Bou Karroum, N., Petit-Cancelier, F., Rodeschini, V., Roche, D., Deprez, B., & Deprez-Poulain, R. Discovery of novel chemotypes as Erap1 metalloprotease inhibitors through fragment-based screening XXVIII EFMC-ISMC, Rome, Italy, 1st-5th Sept.,2024.

Fougiaxis, V.; He, B.; Khan, T.; Vatinel, R.; Koutroumpa, N. M.; Afantidis, A.; Lesire, L.; Sierocki, P.; Deprez, B.; Deprez-Poulain, R.; . Erap Inhibitors : A Medicinal Chemistry Dashboard. In EFMC-ISMC 2024 - XXVIII EFMC International Symposium on Medicinal Chemistry, Roma, IT, 1-5th Sept., 2024.

Bou Karroum, N., He, B., Gealageas, R., Mauvais, F.-X., Warenghem, S., Roignant, M., Kraupner, N., Lam, B. V., Lesire, L., Couturier, C., Leroux, F., Van Endert, P., Deprez, B., & Deprez-Poulain, R. Discovery of novel and selective IRAP inhibitors EFMC-ISMC 2024 - XXVIII EFMC International Symposium on Medicinal Chemistry, Rome, Italy, 1-5th Sept.,2024.

Meurillon, V., Vieira Da Cruz, A., Compagne, N., Jiménez-Castellanos, J.-C., Deprez, B., Willand, N., Pos, K. M., Hartkoorn, R. C., & Flipo, M. Development of 6-substituted quinolines as novel class of Enterobacterale efflux pump inhibitors EFMC-ISMC 2024 - XXVIII EFMC International Symposium on Medicinal Chemistry, Rome, Italy, 1-5th Sept.,2024.

2023

Mourot, L., Chaibi, F. Z., Bou Karroum, N., Abengozar, A., Landry, V., Carré, P., Hanoulle, X., Belouzard, S., Tarricone, A., Desmarets, L., Dubuisson, J., Leroux, F., Deprez, B., & Charton, J. Optimization of F01 a fragment identified in an NMR-based screening, inhibitor of the 3CL protease of SARS-CoV-2 8th Drug Discovery Day, Lille, France, 15th Dec.,2023.

He, B., Warenghem, S., Leroux, F., Vatinel, R., Sierocki, P., Barcherini, V., Kraupner, N., Deprez, B., & Deprez-Poulain, R. Discovery of potent IRAP inhibitors using a combination of docking and SAR 8th Drug Discovery Day, Lille, France, 15th Dec.,2023.

Descamps, F., Bou Karroum, N., Kraupner, N., Bonnet, G., Deprez-Poulain, R., Deprez, B., & Bosc, D. Macrocyclic modulators of IDE for therapeutic applications 8th Drug Discovery Day, Lille, France, 15th Dec.,2023.

Lakli, M., Dumont-Ryckembusch, J., Crespi, V., Charton, J., Vauthier, V., Saad, A. B., Mareux, E., Banet, M., Lapalus, M., Gonzalès, E., Jacquemin, E., Di Meo, F., Deprez, B., Leroux, F., & Falguières, T. THU-267 - Identification of correctors for traffic-defective ABCB4 variants by a high-throughput screening approach,Journal of Hepatology - POSTER PRESENTATIONS: Rare liver diseases (including paediatric and genetic), 22th June,2023.

Vigier, C., Dam, S., Tangara, S., Hamela, C., Piveteau, C., Deprez, B., Kremer, L., Willand, N., Hartkoorn, R. C., & Villemagne, B. Tricyclic spirolactams kill Mycobacteria in Vitro and in Vivo by inhibiting type II NADH Dehydrogenases,57th International Conference on Medicinal Chemistry, RICT, Drug Discovery and Selection, Lille, France, 5th-7th July,2023.

Vasileios, F., Sierocki, P., Piveteau, C., Biela, A., Warenghem, S., Leroux, F., Deprez, B., & Deprez-Poulain, R. Design and optimization of KTGS strategy towards M1 metalloprotease hit identification,57th International Conference on Medicinal Chemistry, RICT, Drug Discovery and Selection, Lille, France, 5th-7th July,2023.

Sierocki, P., Camberlein, V., Tabey-Fleau, C., Gealageas, R., Biela, A., Piveteau, C., Warenghem, S., Dumont, J., Leroux, F., Lesire, L., Deprez, B., & Deprez-Poulain, R. Discovery of the 1st selective ERAP2 modulators able to modulate antigenic presentation in cell, using KTGS,57th International Conference on Medicinal Chemistry, RICT, Drug Discovery and Selection, Lille, France, 5th-7th July,2023.

Meurillon, V., Vieira Da Cruz, A., Compagne, N., Jiménez-Castellanos, J.-C., Deprez, B., Willand, N., Pos, K. M., Hartkoorn, R. C., & Flipo, M. 6-substituted quinolines as Escherichia coli AcrAB-TolC efflux pump inhibitors,57th International Conference on Medicinal Chemistry, RICT, Drug Discovery and Selection, Lille, France, 5th-7th July,2023.

Legru, A., Verdirosa, F., Vo-Hoang, y., Tassone, G., Vascon, F., Thomas, C. A., Sannio, F., Corsica, G., Benvenuti, M., Feller, G., Coulon, R., Piveteau, C., Leroux, F., Rebecca, D.-p., Crowder, M. W., Cendron, L., Pozzi, C., Mangani, S., Docquierb, J.-D., Gavara, L., & Hernandez, J.-F. 1,2,4-Triazole-3-thione-based broad spectrum metallo-b-lactamases inhibitors re-sentitize VIM- and NDM-1-producing clinical isolates to meropenem,57th International Conference on Medicinal Chemistry, RICT, Drug Discovery and Selection, Lille, France, 5th-7th July,2023.

Kraupner, N., Lesire, L., Herledan, A., Warenghem, S., Leroux, F., Deprez, B., Deprez-Poulain, R., & Bosc, D. Crystallography-oriented design of PROTAC® compounds targeting the Insulin Degrading Enzyme (IDE),57th International Conference on Medicinal Chemistry, RICT, Drug Discovery and Selection, Lille, France, 5th-7th July,2023.

He, B., Warenghem, S., Leroux, F., Vatinel, R., Sierocki, P., Barcherini, V., Kraupner, N., Deprez, B., & Deprez-Poulain, R. Design and development of selective carboxylic acid IRAP inhibitor by computer aided rational design,57th International Conference on Medicinal Chemistry, RICT, Drug Discovery and Selection, Lille, France, 5th-7th July,2023.

He, B., Vasileios, F., Sierocki, P., Koutroumpa, N. M., Afantidis, A., Deprez, B., & Deprez-Poulain, R. Potency, selectivity and physicochemical properties of ERAP inhibitors,57th International Conference on Medicinal Chemistry, RICT, Drug Discovery and Selection, Lille, France, 5th-7th July,2023.

Descamps, F., Bou Karroum, N., Kraupner, N., Bonnet, G., Deprez, B., Deprez-Poulain, R., & Bosc, D. Macrocycles modulators of IDE for therapeutic applications,57th International Conference on Medicinal Chemistry, RICT, Drug Discovery and Selection, Lille, France, 5th-7th July,2023.

Compagne, N., Jiménez-Castellanos, J.-C., Meurillon, V., Vieira Da Cruz, A., Piveteau, C., Deprez, B., Willand, N., Pos, K. M., Hartkoorn, R. C., & Flipo, M. Boosting antibiotics: pyridylpiperazine-based inhibitors of E. coli AcrAB-TolC efflux pump,57th International Conference on Medicinal Chemistry, RICT, Drug Discovery and Selection, Lille, France, 5th-7th July,2023.

Chaibi, F. Z., Brier, L., Landry, V., Carré, P., Piveteau, C., Biela, A., Hanoulle, X., Belouzard, S., Desmarets, L., Dubuisson, J., Leroux, F., Deprez, B., & Charton, J. N-acylbenzimidazoles as SARS-CoV-2 3CLpro inhibitors : X-ray structure determination, structure-activity relationships and antiviral activity,57th International Conference on Medicinal Chemistry, RICT, Drug Discovery and Selection, Lille, France, 5th-7th July,2023.

Boulloy, A., Djaout, K., Dreneau, A., Faïon, L., Prieri, M., Piveteau, C., Biela, A., Leroux, F., Dumont, J., Mathys, V., Boarbi, S., Adnet, P.-Y., Deprez, B., Flipo, M., Cooper, C. B., Thompson, A., Baulard, A., & Willand, N. Overcoming antibiotic resistance in tuberculosis: identification and optimization of boosters of nitroimidazole antibiotics,57th International Conference on Medicinal Chemistry, RICT, Drug Discovery and Selection, Lille, France, 5th-7th July,2023.

Bosc, D., Gealageas, R., Jakhlal, J., Kraupner, N., Dinh, C. P., Lesire, L., Landry, V., Tardy, M., Warenghem, S., Herledan, A., Biela, A., Piveteau, C., Leroux, F., Deprez-Poulain, R., & Deprez, B. Discovery, synthesis and structure-activity-properties relationships of new 1,2,3-triazoles, boosters of proteasome inhibitors,57th International Conference on Medicinal Chemistry, RICT, Drug Discovery and Selection, Lille, France, 5th-7th July,2023.

Chaibi, F. Z., Brier, L., Landry, V., Carré, P., Piveteau, C., Biela, A., Hanoulle, X., Moschidi, D., Belouzard, S., Desmarets, L., Rouillé, Y., Dubuisson, J., Leroux, F., Deprez, B., & Charton, J. Identification of N-acylbenzimidazoles as new inhibitors of the main protease of SARS-CoV-2,Journée Thématique SCT-SFV - New antiviral strategies: from bench to bedside, Paris, France, 19th April,2023.

Brier, L., Hassan, H., Hanoulle, X., Landry, V., Moschidi, D., Desmarets, L., Rouillé, Y., Dumont, J., Herledan, A., Warenghem, S., Piveteau, C., Carré, P., Ikherbane, S., Cantrelle, F.-X., Dupré, E., Dubuisson, J., Belouzard, S., Leroux, F., Deprez, B., & Charton, J. New inhibitors of the 3CL protease of SARS-CoV-2 discovered by High-Throughput Screening,Journée Thématique SCT-SFV - New antiviral strategies: from bench to bedside, Paris, France, 19th April,2023.

Chaibi, F. Z., Brier, L., Landry, V., Carré, P., Piveteau, C., Biela, A., Hanoulle, X., Moschidi, D., Belouzard, S., Desmarets, L., Rouille, Y., Dubuisson, J., Leroux, F., Deprez, B., & Charton, J. Discovery and optimization of new antiviral compounds, inhibitors of the main protease of SARS-CoV-2. 30th SCT Young Research Fellows Meeting, Paris, France, 1st-3rd Feb,2023.

Meurillon, V., Vieira Da Cruz, A., Compagne, N., Jiménez-Castellanos, J.-C., Deprez, B., Willand, N., Pos, K. M., Hartkoorn, R. C., & Flipo, M. Synthesis and biological evaluation of 6-substituted quinolines as Escherichia coli efflux pump inhibitors,30th SCT Young Research Fellows Meeting, Paris, France, 1st-3rd Feb,2023.

2022

Tangara, S., Faïon, L., Piveteau, C., Deprez, B., Flipo, M., Willand, N., & Villemagne, B. Synthesis of novel bio-inspired three-dimensional sp3-rich Tricyclic SpiroLactams via stereoselective Meyers lactamization,7th Drug Discovery Day, Lille, France, 16th Dec.,2022.

Vieira Da Cruz, A., Compagne, N., Jiménez-Castellanos, J.-C., Deprez, B., Willand, N., Pos, K. M., Hartkoorn, R. C., & Flipo, M. Synthesis of novel quinolines as inhibitors of AcrAB-TolC efflux pump on Escherichia coli,7th Drug Discovery Day, Lille, France, 16th Dec.,2022.

Fougiaxis, V., He, B., Warenghem, S., Leroux, F., Vatinel, R., Sierocki, P., Deprez, B., & Deprez-Poulain, R. ERAP1 immunomodulation : Combinatorial medicinal chemistry approaches for ligand discovery,7th Drug Discovery Day, Lille, France, 16th Dec.,2022.

Rivière, O., Dumont, J., Leroux, F., Willand, N., Baulard, A., & Djaout, K. HTS on Mycobacterium tuberculosis lineage 1 for the identification of chemical compounds able to resuscitate dormant bacterial populations,Ecole thématique de criblage ETC2022 "Criblage, optimisation et caractérisation de petites molécules pour explorer et soigner le vivant", Eppe-Sauvage, France, 20-23th September,2022.

Djaout, K., Dreneau, A., Faïon, L., Bouloy, A., Prieri, M., Dumont, J., Leroux, F., Bouchut, A., Flipo, M., Willand, N., & Baulard, A. Boosting Pretomanid potency resensitizes ddn mutated M. tuberculosis to nitroimidazoles,Ecole thématique de criblage ETC2022 "Criblage, optimisation et caractérisation de petites molécules pour explorer et soigner le vivant", Eppe-Sauvage, France, 20-23th September,2022.

Aguilar Ayala, D., Eveque, M., Rabodoarivelo, M. S., Octasari Susanto, B., Willand, N., Simonsson, U., Ramón-García, S., & Lucía Quintana, A. Hollow Fiber System for TB: optimization studies with moxifloxacin,EMBO Workshop on Tuberculosis, Paris, France, 12-16th September,2022.

Aguilar Ayala, D., Eveque, M., Rabodoarivelo, M., S., Leding, A., Picó Marco, A., Willand, N., Serbina, N., Simonsson, U., Lucía Quintana, A., & Ramón-García, S. In vitro killing dynamics of the diarylquinolone TBAJ-587 and its main metabolites against Mycobacterium tuberculosis,EMBO Workshop on Tuberculosis, Paris, France, 12-16th September,2022.

Dal Molin, M., Eveque, M., De Giorgi, S., Cioetto Mazzabò, L., Zavala Alvarado, C., Aguilar Ayala, D., Hoffmann, E., Degiacomi, G., Recchia, D., Chiarelli, L., Chhen, J., Dremierre, B., Boutrois, M., Leding, A., Octasari Susanto, B., Simonsson, U., Rosalia Pasca, M., Baulard, A., Lucía Quintana, A., Ramón-García, S., Manina, G., Manganelli, R., Willand, N., Rybniker, J., Serbina, N., Fotouhi, N., & Gaudin, C. Multicentric in-vitro characterization of MPL-204, a new anti-tuberculosis drug candidate, by the ERA4TB collaborative initiative,EMBO Workshop on Tuberculosis, Paris, France, 12-16th September,2022.

Bosc, D., Gealageas, R., Jakhlal, J., Kraupner, N., Dinh, C. P., Lesire, L., Landry, V., Tardy, M., Warenghem, S., Herledan, A., Biela, A., Piveteau, C., Leroux, F., Deprez-Poulain, R., & Deprez, B. Discovery and structure-activity relationships of a new 1,2,3-triazole-bearing chemical series, proteasome inhibitors boosters for anticancer applications,XXVII EFMC International Symposium on Medicinal Chemistry, Nice, France, 4-8th September,2022.

Fougiaxis, V., He, B., Warenghem, S., Leroux, F., Vatinel, R., Sierocki, P., Deprez, B., & Deprez-Poulain, R. ERAP1 immunomodulation : combinatorial medicinal chemistry approaches for ligand discovery,XXVII EFMC International Symposium on Medicinal Chemistry, Nice, France, 4-8th September,2022.

Lesire, L., Deprez-Poulain, R., Landry, V., Bosc, D., Tardy, M., Maillard, C., Dumont, J., Herledan, A., Warenghem, S., De Bruyne, E., Moreaux, J., Delahaye, F., Leroux, F., & Deprez, B. Discovery of bioactive compounds that sensitize cancer cells to proteasome inhibitors,XXVII EFMC International Symposium on Medicinal Chemistry, Nice, France, 4-8th September,2022.

Compagne, N., Vieira Da Cruz, A., Jiménez-Castellanos, J.-C., Deprez, B., Willand, N., Pos, K. M., Hartkoorn, R. C., & Flipo, M. Pyridylpiperazines as efflux pump inhibitors to overcome antimicrobial resistance,29th SCT Young Research Fellows Meeting, Nantes, France, 4-6th July,2022.

Gioia, B., Ruggieri, F., Desmecht, E., Hartkoorn, R. C., & Willand, N. Design and synthesis of nature-inspired libraries to discover new antibacterial agents,29th SCT Young Research Fellows Meeting, Nantes, France, 4-6th July,2022.

He, B., Fougiaxis, V., Warenghem, S., Leroux, F., Vatinel, R., Sierocki, P., Deprez, B., & Deprez-Poulain, R. Design and development of ERAP1 immunomodulators through combinatorial and innovative medicinal chemistry strategies,29th SCT Young Research Fellows Meeting, Nantes, France, 4-6th July,2022.

Kraupner, N., Dinh, C. P., Wen, X., Warenghem, S., Landry, V., Lesire, L., Herledan, A., Piveteau, C., Hennuyer, N., Bosc, D., Staels, B., Leroux, F., Deprez, B., & Deprez-Poulain, R. Identification of indole-based small molecules as activators of insulin degrading enzyme,29th SCT Young Research Fellows Meeting, Nantes, France, 4-6th July,2022.

Ruggieri, F., Hance, P., Gioia, B., Desmecht, E., Hartkoorn, R. C., Roussel, P., Hilbert, J.-L., & Willand, N. A three-step Process to Isolate Large Quantities of Bioactive Sesquiterpene Lactones from Chicorium intybus L. Roots,29th SCT Young Research Fellows Meeting, Nantes, France, 4-6th July,2022.

Tangara, S., Faïon, L., Piveteau, C., Deprez, B., Flipo, M., Willand, N., & Villemagne, B. Synthesis of novel bio-inspired 3-dimensional sp3-rich Tricyclic SpiroLactams via stereoselective Meyers lactamization,29th SCT Young Research Fellows Meeting, Nantes, France, 4-6th July,2022.

Vieira Da Cruz, A., Compagne, N., Jiménez-Castellanos, J.-C., Deprez, B., Willand, N., Pos, K. M., Hartkoorn, R. C., & Flipo, M. Synthesis of novel quinolines as inhibitors of AcrAB-TolC efflux pump on Escherichia coli,29th SCT Young Research Fellows Meeting, Nantes, France, 4-6th July,2022.

2021

Bou Karroum, N., Biela, A., Piveteau, C., Deprez, B., Deprez-Poulain, R., & Bosc, D. Macrocycles in drug discovery: A promising scaffold for enhancing ADME properties and target selectivity,8th EFMC Young Medicinal Chemists’ Symposium, Virtual conference, 9th-10th Sept.,2021.

Kraupner, N., Phi Dinh, C., Wen, X., Landry, V., Leroux, F., Bosc, D., Piveteau, C., Deprez, B., Hennuyer, N., Staels, B., & Deprez-Poulain, R. Identification of indole-based small molecules as activators of insulin degrading enzyme,8th EFMC Young Medicinal Chemists’ Symposium, Virtual conference, 9th-10th Sept.,2021.

Phi Dinh, C., Gealageas, R., Hermant, P., Kraupner, N., Lanthier, C., Warenghem, S., Biela, A., Lenglart, C., Piveteau, C., Tang, W.-J., Leroux, F., Deprez, B., Deprez-Poulain, R., & Bosc, D. KTGS-guided discovery of insulin-degrading enzyme inhibitors : a structure-ADME properties study,8th EFMC Young Medicinal Chemists’ Symposium, Virtual conference, 9th-10th Sept,2021.

Vatinel, R., Sierocki, P., Medve, L., Gealageas, R., Guillaume, V., Rosell, M., Warenghem, S., Leroux, F., Piveteau, C., Deprez, B., & Deprez-Poulain, R. Discovery of hERAP2 modulators via high-throughput screening,8th EFMC Young Medicinal Chemists’ Symposium, Virtual conference, 9th-10th Sept.,2021.

Camberlein, V., Kraupner, N., Bou Karroum, N., Lipka, E., Deprez-Poulain, R., Deprez, B., & Bosc, D. One-pot procedure for the preparation of 1,5-disubstituted 1,2,3-triazoles by in-situ generation of azides,XXVI EFMC International Symposium on Medicinal Chemistry, Virtual conference, 29th Aug. - 2nd Sept.,2021.

Camberlein, V., Sierocki, P., Gealageas, R., Fleau, C., Guillaume, V., Bosc, D., Lesire, L., Warenghem, S., Leroux, F., Deprez, B., & Deprez-Poulain, R. Kinetic target guided synthesis enables the discovery of the first selective nanomolar inhibitors of erap2 for personalized immuno-oncology,XXVI EFMC International Symposium on Medicinal Chemistry, Virtual conference, 29th Aug. - 2nd Sept.,2021.

Bou Karroum, N., Camberlein, V., Kraupner, N., Lipka, E., Deprez-Poulain, R., Deprez, B., & Bosc, D. A safe multi-component reaction for the synthesis of 1,5-disubstituted 1,2,3-triazoles, a scaffold of interest for medicinal chemistry,56th International Conference on Medicinal Chemistry, Interfacing Chemical Biology and Drug Discovery, Virtual Event, 7th-9th July,2021.

Rullás, J., Remuiñán, M., Guijarro, L., Barros, D., Willand, N., Flipo, M., Deprez, B., Baulard, A., Frita, R., Gitzinger, M., Dale, G. E., Pieren, M., & Lociuro, S. Therapeutic efficacy of ethionamide boosted with BVL-GSK098 in an acute murine model of tuberculosis,European Congress of Clinical Microbiology and Infectious Diseases - 31st ECCMID, ePoster, Vienna, Austria, 9th July,2021.

Brier, L., Landry, V., Dumont, J., Hassan, H., Warenghem, S., Herledan, A., Hanoulle, X., Belouzard, S., Dubuisson, J., Leroux, F., Deprez, B., & Charton, J. High throughput screening for the identification of new inhibitors of the 3cl protease of sars-cov-2,56th International Conference on Medicinal Chemistry, Interfacing Chemical Biology and Drug Discovery, Virtual Event, 7th-9th July,2021.

Camberlein, V., Gealageas, R., Fleau, C., Guillaume, V., Bosc, D., Medve, L., Stratikos, E., Warenghem, S., Deprez, B., & Deprez-Poulain, R. First ERAP2 selective inhibitors by kinetic-target guided synthesis to modulate antigen presentation in cancer,56th International Conference on Medicinal Chemistry, Interfacing Chemical Biology and Drug Discovery, Virtual Event, 7th-9th July,2021.

Kraupner, N., Phi Dinh, C., Wen, X., Landry, V., Leroux, F., Bosc, D., Piveteau, C., Deprez, B., Hennuyer, N., Staels, B., & Deprez-Poulain, R. Activators of insulin degrading enzyme : identification of indole-based small molecule,56th International Conference on Medicinal Chemistry, Interfacing Chemical Biology and Drug Discovery, Virtual Event, 7th-9th July,2021.

Phi Dinh, C., Gealageas, R., Hermant, P., Kraupner, N., Lanthier, C., Warenghem, S., Biela, A., Lenglart, C., Piveteau, C., Tang, W.-J., Leroux, F., Deprez, B., Deprez-Poulain, R., & Bosc, D. KTGS-guided discovery of insulin-degrading enzyme inhibitors : a structure-ADME properties study,56th International Conference on Medicinal Chemistry, Interfacing Chemical Biology and Drug Discovery, Virtual Event, 7th-9th July,2021.

Sierocki, P., Medve, L., Fleau, C., Vatinel, R., Khan, T., Gealageas, R., Rosell, M., Guillaume, V., Warenghem, S., Leroux, F., Piveteau, C., Stratikos, E., Deprez, B., & Deprez-Poulain, R. Discovery & binding study of ERAP2 modulators,56th International Conference on Medicinal Chemistry, Interfacing Chemical Biology and Drug Discovery, Virtual Event, 7th-9th July,2021.

Brier, L., Landry, V., Bourgeois, F., Ikherbane, S., Dumont, J., Warenghem, S., Herledan, A., Hanoulle, X., Belouzard, S., Dubuisson, J., Florence, L., Benoit, D., & Julie, C. Discovery of new inhibitors of the SARS-CoV-2 3CL protease by High Throughput Screening 28th SCT Young Research Fellows Meeting, Paris, France, 11th-12th Feb.,2021.

Dinh, C. P., Gealageas, R., Hermant, P., Kraupner, N., Lanthier, C., Warenghem, S., Biela, A., Lenglart, C., Piveteau, C., Tang, W. J., Florence, L., Benoit, D., Deprez-Poulain, R., & Bosc, D. Structure-activity-ADME properties relationship study of inhibitors of Insulin-Degrading Enzyme discovered by KTGS, 28th SCT Young Research Fellows Meeting, Paris, France, 11th-12th Feb.,2021.

Kraupner, N., Lesire, L., Herledan, A., Warenghem, S., Piveteau, C., Landry, V., Leroux, F., Deprez, B., Deprez-Poulain, R., & Bosc, D. PROTAC® an emerging drug discovery technology for target validation, 28th Young Research Fellow Meeting, Paris, France, 11th-12th Feb.,2021.

Nour, B. K., Biela, A., Piveteau, C., Benoit, D., deprez-Poulain, R., & Bosc, D. Macrocycles in drug discovery: A promising scaffold for enhancing ADME properties and target selectivity,28th SCT Young Research Fellow Meeting, Paris, France, 11th-12th Feb.,2021.

Sierocki, P., Vatinel, R., Medve, L., Gealageas, R., Guillaume, V., Rosell, M., warenghem, S., Florence, l., Piveteau, C., Deprez-Poulain, R., & Benoit, D. Discovery of hERAP2 modulators via high throughput screening, 28th SCT Young Research Fellows Meeting, Paris, France, 11th-12th Feb.,2021.

2020

Kraupner, N., Lesire, L., Herledan, A., Warenghem, S., Piveteau, C., Landry, V., Leroux, F., Deprez, B., Deprez-Poulain, R., & Bosc, D. PROTAC® an emerging drug discovery technology for target validation 5th Drug Discovery Day - Conception Synthèse Evaluation et Sélection du principe actif, Lille, France, 16th Dec.,2020.

Tabey-Fleau, C., Camberlein, V., Gealageas, R., Warenghem, S., Guillaume, V., Bosc, D., Benoit, D., & deprez-Poulain, R. Discovery of hERAP 2 inhibitors by Kinetic Target guided synthesis and hit optimization,5th Drug Discovery Day - Conception Synthèse Evaluation et Sélection du principe actif, Lille, France, 16th Dec.,2020.

Vatinel, R., Sierocki, P., Medve, L., Gealageas, R., Guillaume, V., Rosell, M., Warenghem, S., Florence, L., Piveteau, C., Deprez-Poulain, R., & Benoit, D. Discovery of hERAP2 modulation via high-throughput screening approach 5th Drug Discovery Day - Conception Synthèse Evaluation et Sélection du principe actif, Lille, France, 16th Dec.,2020.

Abdesselam, T., Michel, M., Lenglart, C., piveteau, C., Benoit, d., Sushovan, D., M., F., Willand, N., Hartkoorn, R. C., & Villemagne, B. Modulations of a piperidine-based hit identified from a phenotypic-screening, for the treatment of tuberculosis,27th SCT Young Research Fellow Meeting, Caen, France, 29th-31st Janv.,2020.

Andres, M., Hennuyer, N., Van endert, P., Staels, B., Deprez, B., Lancel, S., & Deprez-Poulain, R. New insights into a potential therapeutic target regulating Unfolded Protein Response and subsequent inflammation in liver and muscle, 27th SCT Young Research Fellow Meeting, Caen, France, 29-31 jan.,2020.

Antraygues, K., Maingot, M., Piveteau, C., Bourotte, M., Benoit, D., Lociuro, S., & Willand, N. Design, synthesis and biological evaluation of semisynthetic analogues of natural products for the treatment of bacterial infections,27th SCT Young Research Fellow Meeting, Caen, France, 29th-31st Janv,2020.

Faion, L., Dreneau, A., Djaout, K., Prieri, M., Frita, R., Piveteau, C., Benoit, D., M., F., A., B., & Willand, N. Structure-activity relationship studies within the first chemical family of boosters of the nitroimidazole anti-TB drug pretomanid,27th SCT Young Research Fellow Meeting, Caen, France, 29th-31st Janv.,2020.

Tabey-Fleau, C., Camberlein, V., Gealageas, R., Warenghem, S., Guillaume, V., Bosc, D., Benoit, D., & deprez-Poulain, R. Discovery of hERAP 2 inhibitors by Kinetic Target guided synthesis and hit optimization,27th SCT Young Research Fellow Meeting, Caen, France, 29th-31st Janv.,2020.

2019

Abdesselam, T., Villemagne, B., Piveteau, C., Lenglart, C., Michel, M., M., F., Willand, N., Benoit, D., & Hartkoorn, R. C. Modulations of a piperidine-based hit identified from a phenotypic-screening, for the treatment of tuberculosis 4th Drug Discovery Day - From Concept to Scale up, Lille, France, 17th Dec,2019.

Dreneau, A., Faion, L., Djaout, K., Prieri, M., Frita, R., Piveteau, C., Benoit, D., M., F., A., B., & Willand, N. Discovery, Optimization And Biological Evaluation Of The First Boosters Of The Nitroimidazole Anti-Tb Drug Pretomanid 4th Drug Discovery Day - From Concept to Scale up, Lille, France, 17th Dec,2019.

Camberlein, V., Tabey-Fleau, C., Gealageas, R., Warenghem, S., Guillaume, V., Bosc, D., Leroux, F., Deprez, B., & Deprez-Poulain, R. Discovery of hERAP2 inhibitors by in situ click chemistry and hits optimization 4th Drug Discovery Day - From Concept to Scale up, Lille, France, 17th Dec,2019.

Faion, L., Pintiala, C., Moune, M., Djaout, K., Frita, R., Hanoulle, X., Cantrelle, F.-X., Piveteau, C., Deprez, B., Baulard, A., Willand, N., & M., F. Discovery, Optimization And Biological Evaluation Of The First Low-Molecular-Weight Mycobacterium Tuberculosis Maba (Fabg1) Inhibitors 55th International Conference on Medicinal Chemsitry (RICT), Nantes, France, 3rd-5th July,2019.

Faïon, L., Pintiala, C., Moune, M., Frita, R., Djaout, K., Piveteau, C., Deprez, B., Baulard, A., Willand, N., & Flipo, M. Structural optimization and biological evaluation of Mycobacterium tuberculosis MabA inhibitors 26th SCT Young Research Fellow Meeting, Paris, France, 20th-22nd Feb.,2019.

Camberlein, V., Bosc, D., Gealageas, R., Deprez-Poulain, R., & Deprez, B. New Methodology to Access 1,5-Disubstituted 1,2,3-triazoles 2nd Molecules Medicinal Chemistry Symposium, Barcelona, Spain, 15th-17th May,2019.

Maingot, M., Hoguet, V., Lasalle, M., Piveteau, C., Leroux, F., Herledan, A., Biela, A., Sevin, E., Culot, M., Gosselet, F., Staels, B., Tailleux, A., Deprez, B., & Charton, J. Pharmacokinetic study of Pegylated TGR5 agonists 26th SCT Young Research Fellow Meeting, Paris, France, 20th-22nd Feb.,2019.

Faïon, L., Pintiala, C., Moune, M., Frita, R., Djaout, K., Piveteau, C., Deprez, B., Baulard, A., Willand, N., & Flipo, M. Structural optimization and biological evaluation of Mycobacterium tuberculosis MabA inhibitors 26th SCT Young Research Fellow Meeting, Paris, France, 20th-22nd Feb.,2019.

Andres, M., Hennuyer, N., Van Endert, P., Enee, E., Staels, B., Deprez, B., Lancel, S., & Deprez-Poulain, R. New insights into a potential therapeutic target regulating Unfolded Protein Response and subsequent inflammation in liver and muscle Drug Discovery Day, Lille, France, 18th Jan.,2019.

Lesire, L., Cruz de Casas, P., Rousseau, F., Dumont, J., Brodin, P., Deprez, B., & Leroux, F. Imaging and quantifying aggresome in an automated miniaturized microscopy assay. Drug Discovery Day, Lille, France, 18th jan.,2019.

Camberlein, V., Bosc, D., Gealageas, R., Castillo-Aguilera, O., Deprez-Poulain, R., & Deprez, B. The 1,2,3-triazole ring : a scaffold of interest for medicinal chemistry Drug Discovery Day, Lille, France, 18th Jan,2019.

Castillo-Aguilera, O., Rosell, M., Lam, B. V., Warenghem, S., Guillaume, V., Camberlein, V., Bosc, D., Leroux, F., Deprez, B., & Deprez-Poulain, R. Ullman-derived inhibitors of ER-aminopeptidases (ERAP) Drug Discovery Day, Lille, France, 18th jan,2019.

Castillo-Aguilera, O., Rosell, M., Lam, B. V., Warenghem, S., Guillaume, V., Camberlein, V., Bosc, D., Leroux, F., Deprez, B., & Deprez-Poulain, R. Ullman-derived inhibitors of ER-aminopeptidases (ERAP) 26th SCT Young Research Fellow Meeting, Paris, France, 20th-22nd Feb.,2019.

Andres, M., Hennuyer, N., Van Endert, P., Enee, E., Staels, B., Deprez, B., Lancel, S., & Deprez-Poulain, R. New insights into a potential therapeutic target regulating Unfolded Protein Response and subsequent inflammation in liver and muscle 26th SCT Young Research Fellow Meeting Paris, France, 20th-22nd Feb,2019.

Lesire, L., Cruz de Casas, P., Rousseau, F., Dumont, J., Brodin, P., Deprez, B., & Leroux, F. Imaging and quantifying aggresome in an automated miniaturized microscopy assay. 26th SCT young research Fellow Meeting, Paris, France, 20th-22nd Feb.,2019

2018

Andres, M., Hennuyer, N., van Endert, P., Staels, B., Benoit, D., Lancel, S., & Deprez-Poulain, R. New insights into a potential therapeutic target regulating Unfolded Protein Response and subsequent inflammation in liver and muscle Workshop "Endoplasmic Reticulum function in health and disease", Lucca, Italia, 21st-25th Oct.,2018.

Lesire, L., Rousseau, F., Dumont, J., P., B., Benoit, D., & Florence, L. Imaging and quantifying ERAD pathways in an automated miniaturized microscopy assay Workshop "Endoplasmic reticulum function in health and disease", Lucca, Italia, 21st-25th Oct.,2018.

Leroux, F., Dumont, J., Rousseau, F., Vandeputte, A., Brodin, P., Deprez, B., Vauthier, V., & Falguières, T. Use of quantitative microscopy to identify targeting correctors of ABCB4/MDR3 defective mutants,Ecole thématique de criblage ETC2018 "Chemobiologie : criblage et validation de sondes moléculaires et d'outils thérapeutiques", Marseille, France, 2nd-4th October,2018.

Dufossez, R., Bosc, D., Deprez-Poulain, R., & Deprez, B. Synthesis of macrocycles as inhibitors of a metalloprotease. Journées scientifique de l’Ecole de l'Inserm Liliane Bettencourt, Paris, France, 7th-9th Sept.,2018.

Leroux, F., Dumont, J., Rousseau, F., Vandeputte, A., Brodin, P., Deprez, B., Vauthier, V., & Falguières, T. Use of quantitative microscopy to identify targeting correctors of ABCB4/MDR3 defective mutants,SLAS Europe 2018 Conference and Exhibition, Brussels, Belgium, 27-29th June,2018.

Lesire, L., Rousseau, F., Dumont, J., Benoit, D., & Florence, L. Visualization and quantification of cell aggresome in an automated miniaturized assay Worshop "Cancer and Metabolism", Cambridge, UK, 25th-27th Jun,2018.

Lesire, L., Rousseau, F., Dumont, J., P., B., Benoit, D., & Florence, L. Visualization and quantification of cell aggresome in an automated miniaturized assay 2eme Journée de la Recherche, School of Pharmacy, Lille, France, 11th Jul.,2018.

Faïon, L., Pintiala, C., Moune, M., Frita, R., Djaout, K., Piveteau, C., Deprez, B., Baulard, A., Willand, N., & Flipo, M. Chemical modifications of Mycobacterium tuberculosis MabA inhibitors 25th Young reasearch fellow meeting of SCT, Orleans, France, 5th-7th March,2018.

Prieri, M., Probst, N. P., Frita, R., Sournia-Saquet, A., Bourotte, M., Déprez, B., Baulard, A. R., & Willand, N. Study of the Antitubercular Activity of Thioamide-Analogues Alone or in Combination with 1st and 2nd Generation of Ethionamide-Boosters 25th Young Resaeerch Fellow Meeting of SCT, Orleans, France, 5th-7th March,2018.

Colin, B., Charton, J., & Couturier, C. Validation of a high sensitivity reporter system 25th SCT Young Research Fellow Meeting Orleans, France, 5th-7th March,2018.

Lam, B. V., Gealageas, R., Warenghem, S., Guillaume, V., Camberleyn, V., Bosc, D., Leroux, F., Deprez, B., & Deprez-Poulain, R. Ullman-Derived Inhibitors Of Er-Aminopeptidases (Eraps). 54th International Conference on Medicinal Chemistry , Interfacing Chemical Biology and Drug Discovery, Strasbourg, France, 4th-6th July,2018.

Hermant, P., Piveteau, C., Biela, A., Bosc, D., Deprez, B., & Deprez-Poulain, R. Controlling Plasma Stability Of Hydroxamic Acids: A Medchem Toolbox. 54th International Conference on Medicinal Chemistry , Interfacing Chemical Biology and Drug Discovery, Strasbourg, France, 4th-6th July,2018.

Charton, J., Bosc, D., & Deprez-Poulain, R. MedChem Structure Genius : Free mobile apps to learn drug structures 54th International Conference on Medicinal Chemistry , Interfacing Chemical Biology and Drug Discovery, Strasbourg, France, 4th-6th July,2018.

Charton, J., Bosc, D., & Deprez-Poulain, R. MedChem Structure Genius : Free mobile apps to learn drug structures XXV EFMC International Symposium on Medicinal Chemistry, Llubjana, Slovenia, 2nd-6th Sept,2018.

Hermant, P., Piveteau, C., Biela, A., Bosc, D., Deprez, B., & Deprez-Poulain, R. Controlling Plasma Stability Of Hydroxamic Acids: A Medchem Toolbox. XXV EFMC International Symposium on Medicinal Chemistry, Llubjana, Slovenia, 2nd-6th Sept.,2018.

Lam, B. V., Gealageas, R., Warenghem, S., Guillaume, V., Camberleyn, V., Bosc, D., Leroux, F., Deprez, B., & Deprez-Poulain, R. Ullman-Derived Inhibitors Of Er-Aminopeptidases (Eraps). XXV EFMC International Symposium on Medicinal Chemistry, Ljubljana, Slovenia 2nd-6th Sept.,2018.

Faion, L., Pintiala, M., Moune, M., Frita, R., Djaout, K., Piveteau, C., Deprez, B., Baulard, A., Willand, N., & Flipo, M. Chemical modifications of Mycobacterium tuberculosis MabA inhibitors 26th GP2A – 32nd JFB, Asnelles sur mer, France, 13th-15th Jun.,2018.

Faion, L., Pintiala, M., Moune, M., Frita, R., Djaout, K., Piveteau, C., Deprez, B., Baulard, A., Willand, N., & Flipo, M. Chemical modifications of Mycobacterium tuberculosis MabA inhibitors 2e Journée de la Recherche de la Faculté de Pharmacie, Lille, France, 11th Jul,2018.

2017

Hoguet, V., Lasalle, M., Tailleux, A., Hennuyer, N., Belloy, L., Leroux, F., Piveteau, C., Staels, B., Deprez, B., & Charton, J. Development of new topical intestinal agonists of the bile acid receptor TGR5 for the treatment of type 2 diabetes. 24th Young Research Fellow Meeting of the SCT, Châtenay Malabry, France, 8th-10th February,2017.

Pintiala, C., Moune, M., Bourbiaux, K., Frita, R., Djaout, K., Catherine, P., Deprez, B., Baulard, A., Willand, N., & Flipo, M. Discovery and optimization of Mycobacterium tuberculosis MabA inhibitors 24th Young Research Fellow Meeting of the SCT, Châtenay Malabry, France, 8th-10th February,2017.

Prieri, M., Probst, N. P., Frita, R., Bourotte, M., Deprez, B., A., B., & Willand, N. Boosting The Antitubercular Activity Of Thioamide Compounds Using Inhibitors Of Transcriptional Regulators 24th Young Research Fellow Meeting of the SCT, Châtenay-Malabry, France, 8th-10th February,2017.

Pintiala, C., Moune, M., Bourbiaux, K., Frita, R., Djaout, K., Piveteau, C., Deprez, B., Baulard, A., Willand, N., & Flipo, M. Discovery of the first low-molecular-weight Mycobacterium tuberculosis MabA (FabG1) inhibitors using a fragment-based approach 253rd ACS National Meeting,, San Francisco, CA, USA, , April 2nd-6th,2017.

Gealageas, R., Dassonneville, S., Dumont-Ryckembusch, J., Bosc, D., Lam, B.-V., Deprez, B., Florence, L., & Deprez-Poulain, R. Discovery of hERAP2 inhibitors by high-throughput screening in 384-format. Antigen processing and presentation, Salamanca, Spain, 28 – 31 May,2017.

Gealageas, R., Dassonneville, S., Dumont-Ryckembusch, J., Bosc, D., Lam, B. V., Deprez, B., Leroux, F., & Deprez-Poulain, R. Inhibitors of hERAP2 with unusual Zinc-binding group discovered by High-Throughput Screening in 384-well plate 53rd International Conference on Medicinal Chemistry (RICT), Toulouse, FR, 5th-7th July,2017.

Bosc, D., Hermant, P., Piveteau, C., Biela, A., Gealageas, R., Lam, B. V., Tolajanahary, H., Roignant, M., Bedart, C., Leroux, F., Deprez, B., & Deprez-Poulain, R. Involvement of esterases in the metabolism of hydroxamic acids in plasma determined by high-throughput profiling 53rd International Conference on Medicinal Chemistry (RICT), Toulouse, FR, 5th-7th July,2017.

Dequirez, G., Bourotte, M., Deprez, B., & Willand, N. Suzuki-Miyaura cross coupling using Nickel as catalyst to rapidly access to 3-heteroarylazetidine and 3-arylazetidine. 26th French-Japanese Symposium on Medicinal & Fine Chemistry, Strasbourg, FR, 18th Sept,2017.

Hoguet, V., Lasalle, M., Tailleux, A., Hennuyer, N., Belloy, L., Leroux, F., Piveteau, C., Staels, B., Deprez, B., & Charton, J. Development of new topical intestinal agonists of the bile acid receptor TGR5 for the treatment of type 2 diabetes. Première Journée de la Recherche de la faculté de pharmacie, Lille, FR, 10th July,2017.

Hermant, P., Piveteau, C., Bosc, D., Biela, A., Roignant, M., Deprez, B., & Deprez-Poulain, R. High-throughput profiling of esterases involved in hydroxamate leads hydrolysis Première Journée de la Recherche de la faculté de pharmacie de Lille, Lille, FR, 10th July,2017.

Colin, B., Julie, C., Couturier, C., & Deprez, B. Validation of a high sensitivity reporter system Drug discovery Day-Master Seminar, School of Pharmacy, Lille, France, 7th Dec.,2017.

Faion, L., Pintiala, C., Moune, M., Frita, R., Djaout, K., Piveteau, C., Deprez, B., Baulard, A., Willand, N., & Flipo, M. Optimization of MabA inhibitors as an innovative strategy to fight tuberculosis Drug discovery Day-Master Seminar, School of Pharmacy, Lille, France, 7th Dec.,2017.

Gealageas, R., Dassonneville, S., Dumont-Ryckembusch, J., Bosc, D., Lam, B. V., Hottin, A., Deprez, B., Leroux, F., & Deprez-Poulain, R. Inhibitors of hERAP2 with unusual Zinc-binding group discovered by High-throughput Screening in 384-well plate Drug Discovery Day, Master Seminar, School of Pharmacy, Lille, France, 7th Dec.,2017.

2016

Jakhlal, J., Hennuyer, N., Charton, J., Dumont, J., Dassonneville, S., Hermant, P., Bosc, D., Ronco, C., Leroux, F., Tang, W.-J., Staels, B., Deprez, B., & Deprez-Poulain, R. Discovery of insulin-degraded enzyme inhibitors by kinetic target-guided synthesis: from structure to cellular activity 52nd International Conference on Medicinal Chemistry, RICT 2016, Interfacing Chemical Biology and Drug Discovery, Caen, Normandy, France, 6th-8th July,2016.

Prevet, H., Flipo, M., Sperandio, O., Deprez, B., & Willand, N. Highly functionalized spirohydantoins as 3-dimensional templates for fragment screening. 251st ACS National Meeting, San Diego, California, USA, 13rd-17th Mar.,2016.

Hermant, P., Piveteau, C., Biela, A., Bosc, D., Roignant, M., Deprez, B., & Deprez-Poulain, R. Hit-to-Lead forecasting tools to prevent hydroxamic acids esterasic-metabolism in different species 52nd International Conference on Medicinal Chemistry, RICT 2016, Interfacing Chemical Biology and Drug Discovery, Caen, Normandy, France 6th-8th July,2016.

Hoguet, V., Lasalle, M., Piveteau, C., Leroux, F., Herledan, A., Biela, A., Belloy, L., Hennuyer, N., Boulahjar, R., Sevin, E., Culot, M., Gosselet, F., Staels, B., Tailleux, A., Deprez, B., & Charton, J. Structure-Properties Relationships of PEGylated Small Molecules Agonists of TGR5 52nd International Conference on Medicinal Chemistry, RICT 2016, Interfacing Chemical Biology and Drug Discovery, Caen, Normandy, France, 6th-8th July,2016.

Pintiala, C., Benoit, D., Nicolas, W., & Flipo, M. Improvement of synthetic methods to prepare propiolic acids as fragments for drug discovery. 52nd International Conference on Medicinal Chemistry, RICT 2016, Interfacing Chemical Biology and Drug Discovery, Caen, Normandy, France, 6th-8th July,2016.

Moune, M., Bourbiaux, K., Pintiala, C., Piveteau, C., Deprez, B., Baulard, A., Willand, N., & Flipo, M. Optimization of fragments identified as mycobacterium tuberculosis MABA inhibitors through combinatorial chemistry on solid support 52nd International Conference on Medicinal Chemistry, RICT 2016, Interfacing Chemical Biology and Drug Discovery, Caen, Normandy, France, 6th-8th July,2016.

Hoguet, V., Lasalle, M., Piveteau, C., Leroux, F., Herledan, A., Biela, A., Belloy, L., Hennuyer, N., Boulahjar, R., Sevin, E., Culot, M., Gosselet, F., Staels, B., Tailleux, A., Deprez, B., & Charton, J. Pharmacokinetic study of topical intestinal compounds 23rd Young Research Fellow Meeting, SCT, Lille, France, 15th-17th Feb.,2016.

Boulahjar, R., Belloy, L., Picon, S., Hoguet, V., Hennuyer, N., Lasalle, M., Leroux, F., Piveteau, C., Sevin, E., Culot, M., Gosselet, F., Staels, B., Deprez, B., Tailleux, A., & Charton, J. Discovery and Structure-Activity Relationships of a new class of agonists of the bile acid receptor TGR5. 23rd Young Research Fellow Meeting of SCT, Lille, France, 15th-17th Feb.,2016.

Pintiala, C., Deprez, B., Willand, N., & Flipo, M. Development of synthetic pathways to access propiolic acids as fragments for drug discovery 23rd Young Research Fellow Meeting of the SCT, Lille, France, 15th-17th Feb.,2016.

Hermant, P., Piveteau, C., Biela, A., Bosc, D., Roignant, M., Deprez, B., & Deprez-Poulain, R. Plasma and Microsomal Esterases involvement in the Metabolism of Hydroxamic acids in two species. 2"rd Young Research Fellow Meeting of the SCT, Lille, France, 15th-17th Feb.,2016.

Jakhlal, J., Hennuyer, N., Charton, J., Dumont, J., Dassonneville, S., Bosc, D., Ronco, C., Florence, L., Tang, W. J., Staels, B., Deprez, B., & Deprez-Poulain, R. Kinetic Target-Guided Synthesis: application for Insulin-Degraded Enzyme inhibitors 23rd Young Research Feloow Meeting of the SCT, Lille, France, 15th-17th Feb.,2016.

2015

Flipo, M., Moune, M., Tran, N. C., Pintiala, C., Piveteau, C., Deprez, B., Willand, N., & Baulard, A. Fragment-based screening using tandem mass spectrometry for the discovery of Mycobacterium tuberculosis MabA inhibitors 51st International Conference on Medicinal Chemistry, Avignon, France, 1st-3rd Jul,2015.

Prevet, H. Design and synthesis of new spirohydantoin scaffolds as fragment templates to explore the 3D-chemical space EFMC-YMCS, Antwerp, Belgium, 17th Sept,2015.

Lasalle, M., Tailleux, A., Hennuyer, N., Belloy, L., Piveteau, C., Herledan, A., Hoguet, V., Leroux, F., Gras-Masse, H., Staels, B., Deprez, B., & Charton, J. Optimization and development of novel topical intestinal agonists of the bile acid receptor TGR5 for treatment of diabetes mellitus and associated metabolic diseases. 18th SCI/RSC Symposium on Medicinal Chemistry., Cambridge UK, 13rd-16th Sept.,2015.

Hermant, P., Berte, G., Bosc, D., Marechal, X., Gauriot, M., Hennuyer, N., Leroux, F., Charton, J., Lippens, G., Tang, W. J., Staels, B., Deprez, B., & Deprez-Poulain, R. Lead Characterization and physics properties 19 NMR, Formulation and XRay approach 2nd NovAliX Conference - Biophysics in Drug Discovery, Strasbourg, France, 9th-12th Jun,2015.

Hermant, P., Jakhlal, J., Deprez-Poulain, R., Hennuyer, N., Ronco, C., Bosc, D., Marechal, M., Gauriot, M., Berte, G., Leroux, F., Charton, J., Tang, W. J., Staels, B., & Deprez, B. From in situ click to vivo: Inhibitors of Insulin Degrading Enzyme 22nd SCT Young Fellow Meeting, Biocitech, Romainville, France, 4-6th February,2015.

Prevet, H., Flipo, M., Deprez, B., & Willand, N. Design and synthesis of C-spiranic hydantoin scaffold as 3-D fragment for fragment-based drug discovery approaches 22nd YRFM of the SCT, Biocitech, Romainville, France, 4th-6th Feb,2015.

Tran, N. C., Dhondt, H., Flipo, M., Deprez, B., & Willand, N. Synthesis of C-sp3 enriched isoxazolines as 3-D fragments for fragment-based lead discovery 22nd YRFM of the SCT, Biocitech, Romainville, France, 4th-6th Feb,2015.

Villemagne, B., Tran, N. C., Flipo, M., Piveteau, C., Herledan, A., Delorme, V., Brodin, P., Moune, M., Sperandio, O., Villoutreix, B., Wintjens, R., Wohlkönig, A., Baulard, A., Deprez, B., & Willand, N. Pharmacokinetic profile optimization of EthR inhibitors derived from fragment-based approaches 22nd YRFM of the SCT, Biocitech, Romainville, France, 4th-6th Feb,2015.

2014

Deprez-Poulain, R., Hennuyer, N., Ronco, C., Bosc, D., Marechal, X., Gauriot, M., Berte, G., Leroux, F., Charton, J., Tang, W. J., Staels, B., van Endert, P., & Deprez, B. From in situ click to vivo: inhibitors of Insulin Degrading Enzyme EFMC-ISMC 2014, XXIII International Symposium on Medicinal Chemistry, Lisbon, Portugal, 7th-11th September,2014.

Tran, N. C., Moune, M., Baulard, A., Deprez, B., Flipo, M., & Willand, N. Integrating Fragment-screening and Fragment-based drug design for the discovery of Mycobacterium tuberculosis MabA inhibitors 14th Journée André Verbert, Faculté de Médecine, Lille, France, 11 Sep.,2014.

Prevet, H., Flipo, M., Saas, L., Cocquerel, L., Dubuisson, J., Willand, N., Couturier, C., & Deprez, B. Discovery and synthesis of modulators of the CD81/CLDN-1 complex as new approach to prevent entry of the hepatitis C virus. 50th International Conference on Medicinal Chemistry; Interfacing Chemical Biology and Drug Discovery, Rouen, Normandy, France, 2nd-4th July,2014.

Mathieu, A.-L., Sperandio, O., Pottiez, V., Balzarin, S., Herledan, A., Elkaïm, J. O., Fogeron, M.-L., Piveteau, C., Dassonneville, S., Deprez, B., Villoutreix, B. O., Bonnefoy, N., & Leroux, F. Identification of small inhibitory molecules targeting the Bfl-1 anti-apoptotic protein that alleviate resistance to ABT-737 Rencontres de la Chimie, de la Biologie et de la Physique du PRIM, Lille, France, 26th Jun.,2014.

Tran Ngoc, C., Moune, M., A., B., Deprez, B., M., F., & Willand, N. Integrating Fragment-screening and Fragment-based drug design for the discovery of Mycobacterium tuberculosis MabA inhibitors Rencontres de la Chimie, de la Biologie et de la Physique du PRIM, Lille, France, 26th Jun.,2014.

Prevet, H., Flipo, M., Saas, L., Cocquerel, L., Dubuisson, J., Willand, N., Couturier, C., & Deprez, B. Discovery and synthesis of modulators of the CD81/CLDN-1 complex as new approach to prevent entry of the hepatitis C virus. Rencontres de la Chimie, de la Biologie et de la Physique du PRIM, Lille, France, 26th Jun.,2014.

Zervoudi, E., Hermant, P., Deprez-Poulain, R., & Stratikos, E. Allele-dependent activation of ERAP1 by a small molecule 8th International Workshop on Antigen Processing and Presentation, Philadelphia, USA, 10th-13th Jun,2014.

Bosc, D., Marechal, X., Charton, J., Totobenazara, J., Leroux, F., Piveteau, C., Tang, W. J., Deprez, B., & Deprez-Poulain, R. Discovery via target-guided synthesis and