Save the date : 10th Screening School, Bioscreen 2020
The 10th Summer School of Screening, Bioscreen 2020
will take place in les Hauts-de-France Region
from the 29th September to the 2nd of October 2020
10ème Ecole Thématique de Criblage, Bioscreen 2020
« Criblage, optimisation et caractérisation de petites molécules pour explorer et soigner le vivant »
L’édition lilloise (ETC2020, Bioscreen 2020) aura lieu
dans le centre de conférence du ValJoly, Eppe-Sauvage, du 29 septembre au 2 octobre 2020.
Cette école thématique récurrente sur le criblage moléculaire souhaite regrouper des participants multidisciplinaires, académiques et industriels, afin de stimuler des échanges dans ce domaine. Cette manifestation sera l’occasion de former de nouveaux acteurs, mais également de présenter de nouvelles approches scientifiques et méthodologiques aux participants déjà expérimentés. 
Therapeutic Innovation : Discovery Across Boundaries
U1177 (formerly U761), directed by Pr. Benoit Deprez, is dedicated to drug design, discovery and selection.
The Lab's mission is to design and study compounds that modulates selected molecular targets in a desired way to treat infectious and metabolic diseases.
Our projects engage researchers across physical, chemical and biological sciences to trade ideas and knowledge and sincerely endeavor to validate new therapeutic concepts with drug prototypes and bring drugs candidates to the clinic.
- Developing cutting edge methods for quantitative pharmacology (High Content Screening, Pharmacokinetics)
- Designing the next generation of anti-TB antibiotics : ethionamide boosters.
- Deciphering the role(s) of Insulin Degrading Enzyme in diabetes with several families of modulators.
- Modulating the molecular interplay between intestine, liver and muscles with TGR5 ligands to treat diabetes.
- Developing small chemical modulators of antigenic presentation.
We are open to any type of collaboration with biologists or chemist from academia and industry where medicinal chemistry, in vitro pharmacology and pharmacokinetics enable or accelerate the translation of new therapeutic concept into drug discovery.
Our researchers are committed to the highest standards of scientific quality and integrity in everything they do. We use up-to date electronic lab books to sustainably capitalize knowledge and facilitate collaborations between multiple research sites.
Most of our researchers are also faculty members who teach in PharmD and MSc courses in pharmacy, drug discovery, medicinal chemistry, organic chemistry, and R&D strategies.
A journey with the team
New Positions available!
15-month PostDoc position in ORGANIC & MEDICINAL CHEMISTRY
Deadline May 31, 2020
Latest Publications
(truncated titles)
Lesire, L., et al, High-Throughput Image-Based Aggresome Quantification, SLAS DISCOVERY, 2020: in press link
Villemagne, B., et al Fragment-Based Optimized EthR Inhibitors, ACS Infect Dis,2020, 6(3): 366-378 link
Singh, N., et al, Virtual screening web servers, Brief Bioinform,2020: in press link
Lu, Y., et al, Gly197Arg mutation in protein C causes recurrent thrombosis, Journal of Thrombosis and Haemostasis,2020, 18(5): 1141-1153 link
Herledan, A., et al CETSA-aRPPA for Target engagement, SLAS Disc.,2020, 25(2): 207–214 link
Gyulkhandanyan, A., et al Analysis of protein missense alterations, Mol Genet Genomic Med,2020, e1166 link
Bosc, D., et al Kinetic Target-Guided Synthesis, J. Med. Chem., 2020, 3817−3833 link
Latest Press & News
CAPSTONE ETN selected by UE (MSCA ITN 2020 call)
