Communications

2018

Faïon, L., Pintiala, C., Moune, M., Frita, R., Djaout, K., Piveteau, C., Deprez, B., Baulard, A., Willand, N., & Flipo, M. Chemical modifications of Mycobacterium tuberculosis MabA inhibitors 25th Young reasearch fellow meeting of SCT, Orleans, France, 5th-7th March,2018.

Prieri, M., Probst, N. P., Frita, R., Sournia-Saquet, A., Bourotte, M., Déprez, B., Baulard, A. R., & Willand, N. Study of the Antitubercular Activity of Thioamide-Analogues Alone or in Combination with 1st and 2nd Generation of Ethionamide-Boosters 25th Young Resaeerch Fellow Meeting of SCT, Orleans, France, 5th-7th March,2018.

Colin, B., Charton, J., & Couturier, C. Validation of a high sensitivity reporter system 25th SCT Young Research Fellow Meeting Orleans, France, 5th-7th March,2018.

Lam, B. V., Gealageas, R., Warenghem, S., Guillaume, V., Camberleyn, V., Bosc, D., Leroux, F., Deprez, B., & Deprez-Poulain, R. Ullman-Derived Inhibitors Of Er-Aminopeptidases (Eraps). 54th International Conference on Medicinal Chemistry , Interfacing Chemical Biology and Drug Discovery, Strasbourg, France, 4th-6th July,2018.

Hermant, P., Piveteau, C., Biela, A., Bosc, D., Deprez, B., & Deprez-Poulain, R. Controlling Plasma Stability Of Hydroxamic Acids: A Medchem Toolbox. 54th International Conference on Medicinal Chemistry , Interfacing Chemical Biology and Drug Discovery, Strasbourg, France, 4th-6th July,2018.

Charton, J., Bosc, D., & Deprez-Poulain, R. MedChem Structure Genius : Free mobile apps to learn drug structures 54th International Conference on Medicinal Chemistry , Interfacing Chemical Biology and Drug Discovery, Strasbourg, France, 4th-6th July,2018.

Charton, J., Bosc, D., & Deprez-Poulain, R. MedChem Structure Genius : Free mobile apps to learn drug structures XXV EFMC International Symposium on Medicinal Chemistry, Llubjana, Slovenia, 2nd-6th Sept,2018.

Hermant, P., Piveteau, C., Biela, A., Bosc, D., Deprez, B., & Deprez-Poulain, R. Controlling Plasma Stability Of Hydroxamic Acids: A Medchem Toolbox. XXV EFMC International Symposium on Medicinal Chemistry, Llubjana, Slovenia, 2nd-6th Sept.,2018.

Lam, B. V., Gealageas, R., Warenghem, S., Guillaume, V., Camberleyn, V., Bosc, D., Leroux, F., Deprez, B., & Deprez-Poulain, R. Ullman-Derived Inhibitors Of Er-Aminopeptidases (Eraps). XXV EFMC International Symposium on Medicinal Chemistry, Ljubljana, Slovenia 2nd-6th Sept.,2018.

Faion, L., Pintiala, M., Moune, M., Frita, R., Djaout, K., Piveteau, C., Deprez, B., Baulard, A., Willand, N., & Flipo, M. Chemical modifications of Mycobacterium tuberculosis MabA inhibitors 26th GP2A – 32nd JFB, Asnelles sur mer, France, 13th-15th Jun.,2018.

Faion, L., Pintiala, M., Moune, M., Frita, R., Djaout, K., Piveteau, C., Deprez, B., Baulard, A., Willand, N., & Flipo, M. Chemical modifications of Mycobacterium tuberculosis MabA inhibitors 2e Journée de la Recherche de la Faculté de Pharmacie, Lille, France, 11th Jul,2018.

2017

Hoguet, V., Lasalle, M., Tailleux, A., Hennuyer, N., Belloy, L., Leroux, F., Piveteau, C., Staels, B., Deprez, B., & Charton, J. Development of new topical intestinal agonists of the bile acid receptor TGR5 for the treatment of type 2 diabetes. 24th Young Research Fellow Meeting of the SCT, Châtenay Malabry, France, 8th-10th February,2017.

Pintiala, C., Moune, M., Bourbiaux, K., Frita, R., Djaout, K., Catherine, P., Deprez, B., Baulard, A., Willand, N., & Flipo, M. Discovery and optimization of Mycobacterium tuberculosis MabA inhibitors 24th Young Research Fellow Meeting of the SCT, Châtenay Malabry, France, 8th-10th February,2017.

Prieri, M., Probst, N. P., Frita, R., Bourotte, M., Deprez, B., A., B., & Willand, N. Boosting The Antitubercular Activity Of Thioamide Compounds Using Inhibitors Of Transcriptional Regulators 24th Young Research Fellow Meeting of the SCT, Châtenay-Malabry, France, 8th-10th February,2017.

Pintiala, C., Moune, M., Bourbiaux, K., Frita, R., Djaout, K., Piveteau, C., Deprez, B., Baulard, A., Willand, N., & Flipo, M. Discovery of the first low-molecular-weight Mycobacterium tuberculosis MabA (FabG1) inhibitors using a fragment-based approach 253rd ACS National Meeting,, San Francisco, CA, USA, , April 2nd-6th,2017.

Gealageas, R., Dassonneville, S., Dumont-Ryckembusch, J., Bosc, D., Lam, B.-V., Deprez, B., Florence, L., & Deprez-Poulain, R. Discovery of hERAP2 inhibitors by high-throughput screening in 384-format. Antigen processing and presentation, Salamanca, Spain, 28 – 31 May,2017.

Gealageas, R., Dassonneville, S., Dumont-Ryckembusch, J., Bosc, D., Lam, B. V., Deprez, B., Leroux, F., & Deprez-Poulain, R. Inhibitors of hERAP2 with unusual Zinc-binding group discovered by High-Throughput Screening in 384-well plate 53rd International Conference on Medicinal Chemistry (RICT), Toulouse, FR, 5th-7th July,2017.

Bosc, D., Hermant, P., Piveteau, C., Biela, A., Gealageas, R., Lam, B. V., Tolajanahary, H., Roignant, M., Bedart, C., Leroux, F., Deprez, B., & Deprez-Poulain, R. Involvement of esterases in the metabolism of hydroxamic acids in plasma determined by high-throughput profiling 53rd International Conference on Medicinal Chemistry (RICT), Toulouse, FR, 5th-7th July,2017.

Dequirez, G., Bourotte, M., Deprez, B., & Willand, N. Suzuki-Miyaura cross coupling using Nickel as catalyst to rapidly access to 3-heteroarylazetidine and 3-arylazetidine. 26th French-Japanese Symposium on Medicinal & Fine Chemistry, Strasbourg, FR, 18th Sept,2017.

Hoguet, V., Lasalle, M., Tailleux, A., Hennuyer, N., Belloy, L., Leroux, F., Piveteau, C., Staels, B., Deprez, B., & Charton, J. Development of new topical intestinal agonists of the bile acid receptor TGR5 for the treatment of type 2 diabetes. Première Journée de la Recherche de la faculté de pharmacie, Lille, FR, 10th July,2017.

Hermant, P., Piveteau, C., Bosc, D., Biela, A., Roignant, M., Deprez, B., & Deprez-Poulain, R. High-throughput profiling of esterases involved in hydroxamate leads hydrolysis Première Journée de la Recherche de la faculté de pharmacie de Lille, Lille, FR, 10th July,2017.

Colin, B., Julie, C., Couturier, C., & Deprez, B. Validation of a high sensitivity reporter system Drug discovery Day-Master Seminar, School of Pharmacy, Lille, France, 7th Dec.,2017.

Faion, L., Pintiala, C., Moune, M., Frita, R., Djaout, K., Piveteau, C., Deprez, B., Baulard, A., Willand, N., & Flipo, M. Optimization of MabA inhibitors as an innovative strategy to fight tuberculosis Drug discovery Day-Master Seminar, School of Pharmacy, Lille, France, 7th Dec.,2017.

Gealageas, R., Dassonneville, S., Dumont-Ryckembusch, J., Bosc, D., Lam, B. V., Hottin, A., Deprez, B., Leroux, F., & Deprez-Poulain, R. Inhibitors of hERAP2 with unusual Zinc-binding group discovered by High-throughput Screening in 384-well plate Drug Discovery Day, Master Seminar, School of Pharmacy, Lille, France, 7th Dec.,2017.

2016

Jakhlal, J., Hennuyer, N., Charton, J., Dumont, J., Dassonneville, S., Hermant, P., Bosc, D., Ronco, C., Leroux, F., Tang, W.-J., Staels, B., Deprez, B., & Deprez-Poulain, R. Discovery of insulin-degraded enzyme inhibitors by kinetic target-guided synthesis: from structure to cellular activity 52nd International Conference on Medicinal Chemistry, RICT 2016, Interfacing Chemical Biology and Drug Discovery, Caen, Normandy, France, 6th-8th July,2016.

Prevet, H., Flipo, M., Sperandio, O., Deprez, B., & Willand, N. Highly functionalized spirohydantoins as 3-dimensional templates for fragment screening. 251st ACS National Meeting, San Diego, California, USA, 13rd-17th Mar.,2016.

Hermant, P., Piveteau, C., Biela, A., Bosc, D., Roignant, M., Deprez, B., & Deprez-Poulain, R. Hit-to-Lead forecasting tools to prevent hydroxamic acids esterasic-metabolism in different species 52nd International Conference on Medicinal Chemistry, RICT 2016, Interfacing Chemical Biology and Drug Discovery, Caen, Normandy, France 6th-8th July,2016.

Hoguet, V., Lasalle, M., Piveteau, C., Leroux, F., Herledan, A., Biela, A., Belloy, L., Hennuyer, N., Boulahjar, R., Sevin, E., Culot, M., Gosselet, F., Staels, B., Tailleux, A., Deprez, B., & Charton, J. Structure-Properties Relationships of PEGylated Small Molecules Agonists of TGR5 52nd International Conference on Medicinal Chemistry, RICT 2016, Interfacing Chemical Biology and Drug Discovery, Caen, Normandy, France, 6th-8th July,2016.

Pintiala, C., Benoit, D., Nicolas, W., & Flipo, M. Improvement of synthetic methods to prepare propiolic acids as fragments for drug discovery. 52nd International Conference on Medicinal Chemistry, RICT 2016, Interfacing Chemical Biology and Drug Discovery, Caen, Normandy, France, 6th-8th July,2016.

Moune, M., Bourbiaux, K., Pintiala, C., Piveteau, C., Deprez, B., Baulard, A., Willand, N., & Flipo, M. Optimization of fragments identified as mycobacterium tuberculosis MABA inhibitors through combinatorial chemistry on solid support 52nd International Conference on Medicinal Chemistry, RICT 2016, Interfacing Chemical Biology and Drug Discovery, Caen, Normandy, France, 6th-8th July,2016.

Hoguet, V., Lasalle, M., Piveteau, C., Leroux, F., Herledan, A., Biela, A., Belloy, L., Hennuyer, N., Boulahjar, R., Sevin, E., Culot, M., Gosselet, F., Staels, B., Tailleux, A., Deprez, B., & Charton, J. Pharmacokinetic study of topical intestinal compounds 23rd Young Research Fellow Meeting, SCT, Lille, France, 15th-17th Feb.,2016.

Boulahjar, R., Belloy, L., Picon, S., Hoguet, V., Hennuyer, N., Lasalle, M., Leroux, F., Piveteau, C., Sevin, E., Culot, M., Gosselet, F., Staels, B., Deprez, B., Tailleux, A., & Charton, J. Discovery and Structure-Activity Relationships of a new class of agonists of the bile acid receptor TGR5. 23rd Young Research Fellow Meeting of SCT, Lille, France, 15th-17th Feb.,2016.

Pintiala, C., Deprez, B., Willand, N., & Flipo, M. Development of synthetic pathways to access propiolic acids as fragments for drug discovery 23rd Young Research Fellow Meeting of the SCT, Lille, France, 15th-17th Feb.,2016.

Hermant, P., Piveteau, C., Biela, A., Bosc, D., Roignant, M., Deprez, B., & Deprez-Poulain, R. Plasma and Microsomal Esterases involvement in the Metabolism of Hydroxamic acids in two species. 2"rd Young Research Fellow Meeting of the SCT, Lille, France, 15th-17th Feb.,2016.

Jakhlal, J., Hennuyer, N., Charton, J., Dumont, J., Dassonneville, S., Bosc, D., Ronco, C., Florence, L., Tang, W. J., Staels, B., Deprez, B., & Deprez-Poulain, R. Kinetic Target-Guided Synthesis: application for Insulin-Degraded Enzyme inhibitors 23rd Young Research Feloow Meeting of the SCT, Lille, France, 15th-17th Feb.,2016.

 

2015

Flipo, M., Moune, M., Tran, N. C., Pintiala, C., Piveteau, C., Deprez, B., Willand, N., & Baulard, A. Fragment-based screening using tandem mass spectrometry for the discovery of Mycobacterium tuberculosis MabA inhibitors 51st International Conference on Medicinal Chemistry, Avignon, France, 1st-3rd Jul,2015.

Prevet, H. Design and synthesis of new spirohydantoin scaffolds as fragment templates to explore the 3D-chemical space EFMC-YMCS, Antwerp, Belgium, 17th Sept,2015.

Lasalle, M., Tailleux, A., Hennuyer, N., Belloy, L., Piveteau, C., Herledan, A., Hoguet, V., Leroux, F., Gras-Masse, H., Staels, B., Deprez, B., & Charton, J. Optimization and development of novel topical intestinal agonists of the bile acid receptor TGR5 for treatment of diabetes mellitus and associated metabolic diseases. 18th SCI/RSC Symposium on Medicinal Chemistry., Cambridge UK, 13rd-16th Sept.,2015.

Hermant, P., Berte, G., Bosc, D., Marechal, X., Gauriot, M., Hennuyer, N., Leroux, F., Charton, J., Lippens, G., Tang, W. J., Staels, B., Deprez, B., & Deprez-Poulain, R. Lead Characterization and physics properties 19 NMR, Formulation and XRay approach 2nd NovAliX Conference - Biophysics in Drug Discovery, Strasbourg, France, 9th-12th Jun,2015.

Hermant, P., Jakhlal, J., Deprez-Poulain, R., Hennuyer, N., Ronco, C., Bosc, D., Marechal, M., Gauriot, M., Berte, G., Leroux, F., Charton, J., Tang, W. J., Staels, B., & Deprez, B. From in situ click to vivo: Inhibitors of Insulin Degrading Enzyme 22nd SCT Young Fellow Meeting, Biocitech, Romainville, France, 4-6th February,2015.

Prevet, H., Flipo, M., Deprez, B., & Willand, N. Design and synthesis of C-spiranic hydantoin scaffold as 3-D fragment for fragment-based drug discovery approaches 22nd YRFM of the SCT, Biocitech, Romainville, France, 4th-6th Feb,2015.

Tran, N. C., Dhondt, H., Flipo, M., Deprez, B., & Willand, N. Synthesis of C-sp3 enriched isoxazolines as 3-D fragments for fragment-based lead discovery 22nd YRFM of the SCT, Biocitech, Romainville, France, 4th-6th Feb,2015.

Villemagne, B., Tran, N. C., Flipo, M., Piveteau, C., Herledan, A., Delorme, V., Brodin, P., Moune, M., Sperandio, O., Villoutreix, B., Wintjens, R., Wohlkönig, A., Baulard, A., Deprez, B., & Willand, N. Pharmacokinetic profile optimization of EthR inhibitors derived from fragment-based approaches 22nd YRFM of the SCT, Biocitech, Romainville, France, 4th-6th Feb,2015.

2014

Deprez-Poulain, R., Hennuyer, N., Ronco, C., Bosc, D., Marechal, X., Gauriot, M., Berte, G., Leroux, F., Charton, J., Tang, W. J., Staels, B., van Endert, P., & Deprez, B. From in situ click to vivo: inhibitors of Insulin Degrading Enzyme EFMC-ISMC 2014, XXIII International Symposium on Medicinal Chemistry, Lisbon, Portugal, 7th-11th September,2014.

Tran, N. C., Moune, M., Baulard, A., Deprez, B., Flipo, M., & Willand, N. Integrating Fragment-screening and Fragment-based drug design for the discovery of Mycobacterium tuberculosis MabA inhibitors 14th Journée André Verbert, Faculté de Médecine, Lille, France, 11 Sep.,2014.

Prevet, H., Flipo, M., Saas, L., Cocquerel, L., Dubuisson, J., Willand, N., Couturier, C., & Deprez, B. Discovery and synthesis of modulators of the CD81/CLDN-1 complex as new approach to prevent entry of the hepatitis C virus. 50th International Conference on Medicinal Chemistry; Interfacing Chemical Biology and Drug Discovery, Rouen, Normandy, France, 2nd-4th July,2014.

Mathieu, A.-L., Sperandio, O., Pottiez, V., Balzarin, S., Herledan, A., Elkaïm, J. O., Fogeron, M.-L., Piveteau, C., Dassonneville, S., Deprez, B., Villoutreix, B. O., Bonnefoy, N., & Leroux, F. Identification of small inhibitory molecules targeting the Bfl-1 anti-apoptotic protein that alleviate resistance to ABT-737 Rencontres de la Chimie, de la Biologie et de la Physique du PRIM, Lille, France, 26th Jun.,2014.

Tran Ngoc, C., Moune, M., A., B., Deprez, B., M., F., & Willand, N. Integrating Fragment-screening and Fragment-based drug design for the discovery of Mycobacterium tuberculosis MabA inhibitors Rencontres de la Chimie, de la Biologie et de la Physique du PRIM, Lille, France, 26th Jun.,2014.

Prevet, H., Flipo, M., Saas, L., Cocquerel, L., Dubuisson, J., Willand, N., Couturier, C., & Deprez, B. Discovery and synthesis of modulators of the CD81/CLDN-1 complex as new approach to prevent entry of the hepatitis C virus. Rencontres de la Chimie, de la Biologie et de la Physique du PRIM, Lille, France, 26th Jun.,2014.

Zervoudi, E., Hermant, P., Deprez-Poulain, R., & Stratikos, E. Allele-dependent activation of ERAP1 by a small molecule 8th International Workshop on Antigen Processing and Presentation, Philadelphia, USA, 10th-13th Jun,2014.

Bosc, D., Marechal, X., Charton, J., Totobenazara, J., Leroux, F., Piveteau, C., Tang, W. J., Deprez, B., & Deprez-Poulain, R. Discovery via target-guided synthesis and optimization of Insulin-Degrading Enzyme inhibitors. 97th Canadian Chemistry Conference and Exhibition, Vancouver, Canada, 1st-5th Jun,2014.

Ronco, C., Berte, G., Bosc, D., Marechal, X., Gauriot, M., Hennuyer, N., Leroux, F., Charton, J., Lippens, G., Tang, W. J., Staels, B., Deprez, B., & Deprez-Poulain, R. X-ray crystallography, kinetic target-guided synthesis to unravel the mode of action of insulin degrading enzyme modulators XXIst Young Research Fellow Meeting of the SCT, Montpellier, France, 24th-25th Mar,2014.

Tran Ngoc, C., Moune, M., A., B., Deprez, B., M., F., & Willand, N. Integrating Fragment-screening and Fragment-based drug design for the discovery of Mycobacterium tuberculosis MabA inhibitors XXIst Young Research Fellow Meeting of the SCT, Montpellier, France, 24th-25th Mar,2014.

Prevet, H., Flipo, M., Saas, L., Cocquerel, L., Dubuisson, J., Willand, N., Couturier, C., & Deprez, B. Discovery and synthesis of modulators of the CD81/CLDN-1 complex as new approach to prevent entry of the hepatitis C virus. XXIst Young Research Fellow Meeting of the SCT, Montpellier, France, 24th-25th Mar,2014.

2013

Letronne, F., Laumet, G., Ayral, A.-M., Demiautte, F., Laga, M., Couturier, C., Hot, D., Dumont, J., Hansmannel, F., Mounier, A., Codron, V., Berr, C., Huot, L., Bensmaine, F., Lemoine, Y., Checler, F., Pasquier, F., Luc, B., Deprez, B., Amouyel, P., Deprez, R., Chapuis, J., Gevaert, K., & Lambert, J.-C. An ADAM protein as a new actor of the APP metabolism Alzheimer’s Association International Conference 2013, Boston, MA, U.S.A., 13rd-18th July,2013.

Bosc, D., Marechal, X., Charton, J., Totobenazara, J., Leroux, F., Piveteau, C., Tang, W. J., Deprez, B., & Deprez-Poulain, R. Discovery via Target-Guided synthesis and optimization of insulin-degrading enzyme inhibitors. Banff Symposium on Organic Chemistry, Alberta, Canada, 8th-11th November,2013.

Deprez-Poulain, R., Bosc, D., Leroux, F., Charton, J., Tang, W. J., & Deprez, B. Discovery and optimization of Insulin-Degrading Enzyme inhibitors by screening and target-guided synthesis: from structure to cellular activity. 17th RSC/SCI Medicinal Chemistry Symposium, Cambridge, UK, 8th-11th September,2013.

Dinut, A., A., B., Neut, C., Dubreuil, L., Deprez, B., & Willand, N. Design, Synthesis and Biological Evaluation of Novel Bacterial Topoisomerases IIA Inhibitors International Conference on Medicinal Chemistry, Drug Dicovery and Selection, 49th RICT, Nice, France, 3rd-5th July,2013.

Marechal, X., Bosc, D., Charton, J., Berte, G., Verdelet, T., Dumont, J., Dassonneville, S., Duplan, I., Paquet, C., Herledan, A., Piveteau, C., Staels, B., Leroux, F., Hennuyer, N., Deprez, B., & Deprez-Poulain, R. Inhibition de la différenciation des myoblastes par des inhibiteurs de l’enzyme insulysine développés par click chemistry in situ Congrès de la Société Française de Biochimie et Biologie Moléculaire- Groupe Thématique Enzymes, Paris, France, 4th-6th September,2013.

Berte, G., Elbakali, J., Wen, X., Deprez, B., & Deprez-Poulain, R. Indole priviledged structures: deciphering the regioselectivity of Larock synthesis Journée des Jeunes Chercheurs SCT, Romainville, France, 7th-8th February,2013.

Bosc, D., Marechal, X., Charton, J., Totobenazara, J., Leroux, F., Piveteau, C., Tang, W. J., Deprez, B., & Deprez-Poulain, R. Discovery via in situ click chemistry and structure activity relationships of inhibitors of Insulin-Degrading Enzyme. Journée des Jeunes Chercheurs SCT, Romainville, France, 7th-8th February,2013.

Lasalle, M., Picon, S., Van Obbergen, J., Deprez, B., & Charton, J. Efficient synthesis of novel 5-amino-2-thio-imidazole compounds using propylphosphonic anhydride (®T3P) International Conference on Medicinal Chemistry, Drug Dicovery and Selection, 49th RICT, Nice, France, 3rd-5th July,2013.

Villemagne, B., Flipo, M., Guillet, N., Blondiaux, N., Malaquin, S., Leroux, F., Piveteau, C., Villeret, V., Villoutreix, B., Sperandio, O., Wintjens, R., Wohlkönig, A., Brodin, P., Baulard, A., Deprez, B., & Willand, N. Fragment-based approaches for the discovery of new EthR inhibitor pharmacophores to fight tuberculosis. Rencontres PRIM de la Chimie, de la Biologie et de la Physique, Lille, France, 28th May,2013.

Bosc, D., Marechal, X., Charton, J., Verdelet, T., Berte, G., Totobenazara, J., Leroux, F., Piveteau, C., Tang, W. J., Deprez, B., & Deprez-Poulain, R. Discovery via in situ click chemistry and structure activity relationships of inhibitors of Insulin-Degrading Enzyme Rencontres PRIM de la Chimie, de la Biologie et de la Physique, Lille, France, 28th May,2013.

Saas, L., Montpellier, C., Cocquerel, L., Dubuisson, J., Deprez, B., & Couturier, C. Mise au point d'un test cellulaire de criblage haut-deébit pour identifier les inhibiteurs d'entrée du virus de l'hépatite C. Rencontres PRIM de la Chimie, de la Biologie et de la Physique, Lille, France, 28th May,2013.

Berte, G., Elbakali, J., Wen, X., Deprez, B., & Deprez-Poulain, R. Indole priviledged structures: deciphering the regioselectivity of Larock synthesis Rencontres PRIM de la Chimie, de la Biologie et de la Physique, Lille, France, 28th May,2013.

Bosc, D., Marechal, X., Charton, J., Verdelet, T., Berte, G., Totobenazara, J., Leroux, F., Piveteau, C., Tang, W. J., Deprez, B., & Deprez-Poulain, R. Discovery via in situ click chemistry and structure activity relationships of inhibitors of Insulin-Degrading Enzyme International Conference on Medicinal Chemistry, Drug Dicovery and Selection, 49th RICT, Nice, Franace, 3rd-5th July,2013.

Villemagne, B., Flipo, M., Guillet, N., Blondiaux, N., Malaquin, S., Leroux, F., Piveteau, C., Villeret, V., Villoutreix, B., Sperandio, O., Wintjens, R., Wohlkönig, A., Brodin, P., Baulard, A., Deprez, B., & Willand, N. Fragment-based approaches for the discovery of new EthR inhibitor pharmacophores to fight tuberculosis. International Conference on Medicinal Chemistry, Drug Dicovery and Selection, 49th RICT, Nice, France, 3rd-5th July,2013.

2012

Deprez-Poulain, R., Charton, J., Totobenazara, J., Gauriot, M., Landry, V., Dumont, J., Leroux, F., Guo, Q., Tang, W. J., & Deprez, B. Discovery of Insulin-Degrading Enzymle Modulators:challenges for the validation of a cryptidase as a biological target EFMC-ISMC 2012 22nd International Symposium on Medicinal Chemistry, Berlin, Germany, 2nd-6th September,2012.

Flipo, M., Desroses, M., Piveteau, C., Leroux, F., Wohlkönig, A., Wintjens, R., Brodin, P., Villeret, V., Baulard, A., Deprez, B., & Willand, N. Boosting ethionamide by targeteing the transcriptional repressor EthR. AN emerging approach in tuberculosis drug development. 4th ITS Meeting, Lille, France, 8th-9th October,2012.

Deprez-Poulain, R., Charton, J., Totobenazara, J., Gauriot, M., Landry, V., Dumont, J., Leroux, F., Guo, Q., Tang, W. J., & Deprez, B. Discovery of Insulin-Degrading Enzymle Modulators:challenges for the validation of a cryptidase as a biological target 4th ITS Meeting, Lille, France, 8th-9th October,2012.

Piveteau, C., Dassonneville, S., Dumont, J., Deprez-Poulain, R., Jallouli, Y., Beghyn, T., Leroux, F., & Deprez, B. Taking up the ADME-PK Challenge 4th ITS Meeting, Lille, France, 8th-9th October,2012.

Dinut, A., Willand, N., & Deprez, B. Application de la réaction de click-chemistry à la synthèse de nouveaux inhibiteurs de topoisomérases IIA bactériennes. 3rd Scientific Day PRIM, Lille, France, 29th Jun,2012.

Flipo, P., Gardez, S., Peroy, M., Tilte, M., Tartar, A., Deprez, B., & Deprez-Poulain, R. Global NCE for the evaluation of the pharmaceutical innovation in 2011. 3rd Scientific Day PRIM, Lille, France, 29th Jun,2012.

Flipo, M., Dinut, A., Desroses, M., Piveteau, C., Leroux, F., Wohlkönig, A., Wintjens, R., Brodin, P., Baulard, A., Deprez, B., & Willand, N. Boosting ethionamide by targeting the transcriptional repressor EthR. An emerging approach in tuberculosis drug development. 3rd Scientific Day PRIM, Lille, France, 29th Jun,2012.

Villemagne, B., Guillet, N., Flipo, M., Blondiaux, N., Malaquin, S., Leroux, F., Piveteau, C., Villeret, V., Villoutreix, B., Sperandio, O., Brodin, P., Baulard, A., Deprez, B., & Willand, N. Combining fragment-based drug design and X-ray crystallography for the development of Ethionamide boosters as a new strategy to fight MDR-tuberculosis. EFMC-ISMC 2012 22nd International Symposium on Medicinal Chemistry, Berlin, Germany, 2nd-6th September,2012.

Villemagne, B., Guillet, N., Blondiaux, N., Malaquin, S., Leroux, F., Piveteau, C., Villeret, V., Brodin, P., Christophe, T., Jeon, H. K., Villoutreix, B., Sperandio, O., Baulard, A., Deprez, B., & Willand, N. Fragment-based drug design and X-ray crystallography towards the optimization of potent ethionamide boosters as a new strategy to fight MDR-tuberculosis. 244th American Chemical Society National Meeting & Exposition, Philadelphia, USA, 19th-23rd August,2012.

Flipo, M., Dinut, A., Desroses, M., Piveteau, C., Leroux, F., Wohlkönig, A., Wintjens, R., Brodin, P., Baulard, A., Deprez, B., & Willand, N. Boosting Ethionamide by targeting the transcriptional repressor EthR. An emerging approach in tuberculosis drug development. RICT Interfacing Chemical Biology and Drug Discovery, 48th International Conference on Medicinal Chemistry, Poitiers, France, 4th-6th July,2012.

Picon, S., Aknin, K., Leroux, F., Dubanchet, B., Hennuyer, N., Lasalle, M., Vermey, A., Baron, M., Tournaire, X., Daoudi, M., Lestavel, S., Staels, B., Deprez, B., Tailleux, A., & Charton, J. Discovery and Structure-Activity Relationships of arylsulfonamides as a new class of agonists of the bile acid receptor TGR5 RICT Interfacing Chemical Biology and Drug Discovery, 48th International Conference on Medicinal Chemistry, Poitiers, France, 4th-6th July,2012.

Flipo, P., Gardez, S., Peroy, M., Tilte, M., Tartar, A., Deprez, B., & Deprez-Poulain, R. Global NCE for the evaluation of pharmaceutical innovation in 2011. RICT Interfacing Chemical Biology and Drug Discovery, 48th International Conference on Medicinal Chemistry, Poitiers, France, 4th-6th July,2012.

Wen, X., Elbakali, J., Deprez, B., & Deprez-Poulain, R. Efficient Synthesis of 1,3-Benzazoles, Privileged Scaffolds in Drug Discovery XIXème Journée Jeunes Chercheurs, Paris, France, 2nd-3rd Feb.,2012.

2011

Villemagne, B., Guillet, N., Blondiaux, N., Malaquin, S., Leroux, F., Piveteau, C., Villeret, V., Brodin, P., Christophe, T., Villoutreix, B., Sperandio, O., Baulard, A., Deprez, B., & Willand, N. Development of fragment based approaches for the design and optimization of potent inhibitors of mycobacterial transcriptional repressor. Annual One-Day Meeting on Medicinal Chemistry of SRC & KVCV: Emerging Targets and Treatments: Opportunities and Challenges for Drug Design, Ghent, France, 25th Nov.,2011.

Deprez-Poulain, R., Gauriot, M., Charton, J., Leroux, F., Landry, V., Totobenazara, J., Elbakali, J., Wen, X., Guo, Q., Tang, W. J., & Deprez, B. Discovery of Insulin Degrading-Enzyme modulators: challenges for the validation of a cryptidase as a biological target SCI-RSC Medicinal Chemistry, Cambridge, UK, 11th-14th Sep.,2011.

Soueidan, M., Jida, M., Bousquet, T., Pellegrini, S., Agbossou-Niedercorn, F., & Pelinski, L. Multicomponent reaction: key access to biomolecules Scientific Day PRIM, Pasteur Institute, Lille, France, 28-29th Mar,2011.

Lasalle, M., Boulenger, M., Luc Laurentowski, L., Sarah Merlen, S., Charlotte Vandeputte, C., Gras, H., Tartar, A., & Deprez-Poulain, R. Global NCEs for a better evaluation of pharmaceutical innovation RICT Drug Discovery and Selection, 47th International Conference on Medicinal Chemistry, Lyon, France, 6th-8th July,2011.

Crauste, C., Villemagne, B., Villery, E., Baulard, A., Deprez, B., & Willand, N. Development of Surface Plasmon Resonance Methodologies to Quantify Activities of Potent Inhibitors of EthR, a Mycobacterial Transcriptional Repressor. RICT Drug Discovery and Selection, 47th International Conference on Medicinal Chemistry, Lyon, France, 6th-8th July,2011.

Flipo, M., Desroses, M., Piveteau, C., Leroux, F., Brodin, P., Baulard, A., Deprez, B., & Willand, N. Ethionamide Boosters as a new strategy to fight tuberculosis: from the in vivo proof of concept to the disovery of a preclinical candidate. RICT Drug Discovery and Selection, 47th International Conference on Medicinal Chemistry, Lyon, France, 6th-8th July,2011.

Villemagne, B., Guillet, N., Blondiaux, N., Malaquin, S., Leroux, F., Piveteau, C., Villeret, V., Brodin, P., Thierry, C., Jeon, H. K., Villoutreix, B. O., Sperandio, O., Baulard, A., Deprez, B., & Willand, N. Development of fragment based approaches for the design and optimization of potent inhibitors of mycobacterial transcriptional repressor. RICT Drug Discovery and Selection, 47th International Conference on Medicinal Chemistry, Lyon, France, 6th-8th July,2011.

2010

Villemagne, B., Malaquin, S., Guillet, N., Blondiaux, N., Brodin, P., Villeret, V., Villoutreix, B. O., Sperandio, O., Baulard, A., Deprez, B., & Willand, N. Rapid Discovery of EthR Inhibitors Using Fragment Based Drug Design 46th RICT International Conference on Medicinal Chemistry, Reims, France, 30th Jun.-2nd Jul,2010.

Malaquin, S., Host, H., Laconde, G., Deprez-Poulain, R., Leroux, F., & Deprez, B. Conception of protein-protein interactions inhibitors: screening and libraries synthesis 10th Journée André Verber, Lille, France, 15th Sep,2010.

Jida, M., Malaquin, S., Deprez-Poulain, R., Laconde, G., & Deprez, B. Synthesis of 5- and 6-membered Lactams via Ugi Reaction Under Microwave Solvent Free Assistance 46th RICT International Conference on Medicinal Chemistry, Reims, France, Jun 30th - Jul 2nd,2010.

Gauriot, M., Leroux, F., Landry, V., Tang, W. J., Guo, Q., Deprez, B., Charton, J., & Deprez-Poulain, R. Pharmacomodulation of a substrate-dependent modulator of Insulin-Degrading Enzyme. 46th RICT International Conference on Medicinal Chemistry, Reims, France, 30th Jun. - 2nd Jul.,2010.

Jida, M., Laconde, G., Deprez, B., & Deprez-Poulain, R. Synthesis of 5- and 6-membered lactams via Ugi and Meyers reactions under microwave solvent free assistance JCO 2010 - Journées de Chimie Organique, Palaiseau, Ecole Polytechnique, France, 21st-23rd Sep.,2010.

Villemagne, B. Validation of a Fragment-Based Drug Design approach for the rapid discovery of EthR inhibitors: Linking Strategy Scientific Day PRIM, Lille, 10th Mar,2010.

Villemagne, B. Validation of a Fragment-Based Drug Design approach for the rapid discovery of EthR inhibitors: Growing strategy Scientific Day PRIM, Lille, 10th Mar,2010.

Gluszok, S., Cousaert, N., Michaut, A., Hamdane, M., Becque, S., Landry, V., Leroux, F., Buée, L., Bienaymé, H., & Deprez, B. Vers de nouveaux inhibiteurs de GSK-3 : application au traitement de la maladie d'Alzheimer Scientific Day PRIM, Lille, 10th Mar,2010.

Flipo, M., Guillet, N., Desroses, M., Blondiaux, N., Villeret, V., Baulard, B., Deprez, B., & Willand, W. Design, parallel synthesis and high-throughput screening of N-aryloxy- and N-arylsulfanylacetamide library as potential EthR ligands and boosters of ethionamide activity. 239th ACS National Meeting, San Francisco, California, 21st-25th Mar,2010.

Flipo, M., Guillet, N., Desroses, M., Blondiaux, N., Villeret, V., Baulard, B., Deprez, B., & Willand, W. Design, parallel synthesis and high-throughput screening of N-aryloxy- and N-arylsulfanylacetamide library as potential EthR ligands and boosters of ethionamide activity. Scientific Day PRIM, Lille, 10th Mar,2010.

Maingot, L., Leroux, F., Delaroche, S., Landry, V., Charton, J., Sperandio, O., Villoutreix, B. O., Deprez-Poulain, R., & Deprez, B. Discovery of Novel Aggrecanase-2 inhibitors by HTS and hit-to-lead optimisation. Scientific Day PRIM, Paris, 10th Mar,2010.

Maingot, L., Leroux, F., Delaroche, S., Landry, V., Charton, J., Deprez-Poulain, R., & Deprez, B. Discovery of Novel Aggrecanase-2 inhibitors by HTS and hit-to-lead optimisation. XVIIième Journée Jeunes Chercheurs SCT, Paris, 5th February,2010.

Jida, M., Malaquin, S., Deprez-Poulain, R., Deprez, B., & Laconde, G. Utilisation de conditions microondes sans solvant pour la réaction de Meyers XVII ième Journée Jeunes Chercheurs SCT, Paris, 5th February,2010.

2009

Deprez-Poulain, R., Leroux, F., Landry, V., Gauriot, M., Totobenazara, J., Guo, Q., Tang, W.-J., Charton, J., & Deprez, B. Discovery of Insulin Degrading Enzyme Modulators 15th RSC-SCI Medicinal Chemistry, Cambridge, UK, 6-9th September,2009.

Jida, M., Warnault, P., Deprez-Poulain, R., Deprez, B., & Laconde, G. Utilisation de conditions microondes sans solvant pour la réaction de Meyers 23eme journées Franco-Belges de pharmacochimie, Mons, Belgium, 28-29th May,2009.

Maingot, L., Leroux, F., Delaroche, S., Landry, V., Charton, J., Deprez-Poulain, R., & Deprez, B. Discovery of Novel Aggrecanase -2 Inhibitors by screening and optimisation. 3rd International Symposium on Advances in Synthetic and Medicinal Chemistry, Kiev, Ukraine, August 23 - 27,2009.

Deprez-Poulain, R., Flipo, M., Charton, J., & Deprez, B. Relever le défi de l'ADME: Etude de cas d'un inhibiteur de la metalloprotease PfAM1 comme antimalarique. 23èmes journées franco-belges de pharmacochimie, Mons, Belgium, May 28-29,2009.

Leroux, F., Zarka, M., Delaroche, S., Bouchet, J., Basmaciogullari, S., Déprez, B., & Benichou, S. Screening for Inhibitors of CD4-PLSCR1 Interaction, a New Target for Therapy of HIV-1 Infection 15th SBS Annual Conference, Lille, France, 26-30 Apr.,2009.

Leroux, F., Host, H., Landry, V., Delaroche, S., Maingot, L., Charton, J., Deprez, B., & Déprez-Poulai . An efficient platform to study metalloproteases (P4006) 15th SBS Annual Conference, Lille, France, 26-30 Apr.,2009.

Host, H., Malaquin, S., Dausque, G., Laconde, G., Déprez, R., Leroux, F., & Déprez, B. Conception of protein-protein interactions inhibitors: screening and libraries synthesis 15th SBS Annual Conference, Lille, France, 26-30 Apr.,2009.

Leroux, F., Landry, V., Host, H., Delaroche, S., Gauriot, M., Déprez, B., Déprez-Poulain, R., & Charton, J. Biological screening for identifying inhibitors of the Insulin Degrading Enzyme. XVIème Journée Jeunes Chercheurs, SCT, Paris, France, February 5th,2009.

Cousaert, N. Conception et synthèse d'inhibiteurs de métalloprotéases et de cibles à ligand acide.(Ph.D.), Université Lille Nord de France, Lille, 19th Nov., 2008.

Bourin, A., Laconde, G., Leroux, F., Delaroche, S., Reboule, I., Deprez, B., & Beghyn, T. Taking up the ADME challenge. XVIème Journée Jeunes Chercheurs, Paris, France, February, 5th,2009.

Host, H., Malaquin, S., Laconde, G., Deprez-Poulain, R., Leroux, F., & Deprez, B. Conception of protein-protein interactions inhibitors: screening and libraries synthesis XVIème Journée Jeunes Chercheurs, SCT, Paris, France, 5th February,2009.

2008

Leroux, F., Landry, V., Host, H., Delaroche, S., Gauriot, M., Déprez, B., Déprez-Poulain, R., & Charton, J. Biological screening for identifying inhibitors of the Insulin Degrading Enzyme. XVIème Journée Jeunes Chercheurs, SCT, Paris, France, February 5th,2009

Charton, J., Flipo, M., Hocine, A., Deprez, B., & Deprez-Poulain, R. Hydroxamates: hits, leads and/or drugs? A case study Small Molecules, Antibodies and Natural Products: Multiple Faces of Medicinal Chemistry/Annual One-Day Meeting on Medicinal Chemistry., Katholieke Universiteit Leuven, Belgium, November 7, 2008,2008.

Desroses, M., Dirie, B., Willand, N., Flipo, M., Carette, X., Bifani, P., Singhal, A., Leroux, F., Déprez-Poulain, R., Frenois, F., Aumercier, M., Locht, C., Villeret, V., Déprez, B., & Baulard, A. Ethionamide Boosters: a new strategy to fight Tuberculosis XXth International Symposium on Medicinal Chemistry, Vienna, Austria, 31st Aug.-4th Sept.,2008.

Nicolas Willand, Benoit Folléas, Jean-Louis Brayer, André Tartar,,Benoit Deprez.
IDABO: a convenient reagent for the one-step synthesis of tropinone derivatives
43èmes Rencontres Internationales de Chimie Thérapeutique, Faculté de Pharmacie de Lille, 4-6 Juillet 2007.

2007

Nicolas Willand, Benoit Folléas, Mikael Cauche, Jean-Louis Brayer, André Tartar, Benoit Deprez. A One-step "Diversity Oriented Synthesis" strategy starting from , and -keto-acid platforms. 43èmes Rencontres Internationales de Chimie Thérapeutique, Faculté de Pharmacie de Lille, 4-6 Juillet 2007.

Nicolas Willand, Bertrand Dirié, Zoé Lens, Vincent Villeret, Prakash Rucktooa, Patrick Toto, Alain Baulard and Benoit Deprez.
A new in situ Click-chemistry approach: application for the discovery of EthR ligands. 43èmes Rencontres Internationales de Chimie Thérapeutique, Faculté de Pharmacie de Lille, 4-6 Juillet 2007.

Nicolas Cousaert, Rebecca Deprez-Poulain, Benoît Deprez. Original loading and Suzuki conditions for the solid phase synthesis of sartans.43èmes Rencontres Internationales de Chimie Thérapeutique, Faculté de Pharmacie de Lille, 4-6 Juillet 2007.

Rebecca F. Deprez-Poulain; Julie Charton ; Virginie Leroux; Benoit P. Deprez Convenient synthesis of 4H-1,2,4-triazole-3(2H)-thiones using di-2-pyridyl-thionocarbonate 43èmes Rencontres Internationales de Chimie Thérapeutique, Faculté de Pharmacie de Lille, 4-6 Juillet 2007.

Terence Beghyn, Guillaume Laconde, Antoine Héninot, Benoit Deprez New approach to new antiparasitic agents. Application to the discovery of antimalarial series of compounds. 43èmes Rencontres Internationales de Chimie Thérapeutique, Faculté de Pharmacie de Lille, 4-6 Juillet 2007.

2006

Candide HOUNSOU, Sylvain DELAROCHE, Aurore MULLER, Valérie LANDRY, Bertrand DIRIE, Vincent Villeret, Alain BAULARD, Nicolas WILLAND, Benoît DEPREZ
Tuberculosis : Screening for Ligands Of The Transcriptional Repressor EthR
12th Annual Conference & Exhibition, SBS, Advancing Drug Discovery : from better Hits to better candidates, Seattle, Washington, USA, Sept 17-21, 2006 (poster)

A.R. Baulard, B. Dirie, C. Hounsou, V. Landry, N. Willand, F. Frenois, A. Muller, M. Aumercier, C. Locht, B. Deprez, V. Villeret
Identification of EthR Ligands that synergize Ethionamide action on Mycobacterium tuberculosis.
Colloque de l'association française de cristallographie, 10-13 Juillet 2006

Terence Beghyn, Marion Flipo, Virginie Leroux, Rébecca Déprez-Poulain, Benoit Déprez
eADME and in silico ADME methods for the rapid evaluation during Hit to Lead Optimization
42èmes Rencontres Internationales de Chimie Thérapeutique, Marseille, Juillet 2006, Poster

Julie Charton, Nicolas Cousaert, Christophe Bochu, Nicolas Willand, Benoit Déprez, Rébecca Déprez-Poulain
A mitsunobu reaction to anchor acidic ambident heterocycles on a benzylalcohol resin
42èmes Rencontres Internationales de Chimie Thérapeutique, Marseille, Juillet 2006, Poster

Marion Flipo, Virginie Leroux, Isabelle Florent, Benoit Déprez, Rébecca Déprez-Poulain
Développement de nouveaux inhibiteurs de PFA-M1, une Zinc-metalloprotease de plasmodium falciparum.
42èmes Rencontres Internationales de Chimie Thérapeutique, Marseille, Juillet 2006, Poster

Nicolas Cousaert, Nicolas Willand, Patrick Toto, Jean-Claude Gesquière, Benoit Déprez
Synthèse sur support solide de l'irbésartan dérivé biphényltétrazole.
20ème journées franco-belges de Pharmacochimie, Lille, 1-2 juin 2006, Poster

Julie Charton, Nicolas Cousaert, Christophe Bochu, Nicolas Willand, Benoit Déprez, Rébecca Déprez-Poulain
Ancrage d'hétérocycles acides sur une résine hydroxybenzyl pour la synthèse de composés à tête polaire acide
20ème journées franco-belges de Pharmacochimie, Lille, 1-2 juin 2006, Poster

2005

A. Muller, C. Hounsou, B. Dirie, V. Landry, N. Willand, F. Frenois, V. Villeret, M. Aumercier, C. Locht, B. Deprez
Identification of EthR ligands that synergize ethionamide action on mycobacterium tuberculosis.
45th ICAAC, Washington, 16-19 Dec 2005

Charruault L., Deprez B.
Design and synthesis of a targeted library based on a novel acidic template
41èmes Rencontres Internationales de Chimie Thérapeutique, Paris, Juillet 2005. Poster

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