Welcome to our website!
U761, directed by Pr. Benoit Deprez, is dedicated to drug design, discovery and selection.
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Our project teams gather chemists and biologists cooperating with scientists who work on novel target discovery and validation. Our mission is to design and prepare ligands modulating the effects of these proteins in vitro first and in animal model ultimately. These compounds serve first as pharmacological probe to validate therapeutic approaches and then as drug prototypes.
Our know-how is a combination of academic and industrial experience. It spans from medicinal chemistry, parallel synthesis and library management to high throughput screening bioanalysis and early DMPK. We foster close ties with industrial teams and academic researchers, especially with structural biologists and molecular modellers. We are open to any collaboration where medchem, screening and DMPK can unlatch new drug research and accelerate the translation of new therapeutic concept into drug discovery.
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U761 has received the above national accreditations for:
- PAI for Equipex Imaginex BioMed
- Prize for innovating enterprise PharmaRedux
- Ibisa label for the screening, ADME and chemistry platform (CDithem)
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New PostDoc positions for 2012
See offers & procedures
Campagne de recrutement d'ATER deadline 6 mai 2012 !
Latest Publications
Wen, X., et al. Tet. Lett.,2012, 53(19): 2440-2443 doi:10.1016/j.tetlet.2012.03.007
Villemagne, B., et al. Eur. J. Med. Chem.,2012, 51: 1–16. doi: 10.1016/j.ejmech.2012.02.033
Elbakali, J., et al. NEP inhibitors Med.Chem.Comm.,2012: just accepted. doi:10.1039/C2MD00287F
Flipo, M., et al Ethionamide Boosters Part 2: J.Med. Chem. 2012 just accepted. doi: 10.1021/jm200825u
Beghyn, T. et al. Drug-to-Genome-to-Drug, Step 2 J.Med. Chem.,2012 just accepted doi: 10.1021/jm201422e
Aknin, K., et al. Squaric acid in Ugi reaction in Tet Lett ,2012, 53: 458-461. doi:10.1016/j.tetlet.2011.11.077
Deprez R. et al Ullmann–Finkelstein rxns in Eur. J. Med.Chem. 2011, 46, 3867-3876 doi:10.1016/j.ejmech.2011.05.056
Bonnel, D., et al J. MALDI imaging techniques . Bioanalysis,2011, 3(12): 1399-1406. doi: 10.4155/bio.11.88
Flipo, M. et al Ethionamide boosters in J. Med.Chem. 2011, 54(8): 2994-3010. doi:10.1021/jm200076a
Beghyn, T. et al Drug to Genome to Drug in J. Med.Chem. 2011, 54(9): 3222–3240. doi:10.1021/jm1014617
Jida, M. et al. N-benzyl-2-substituted piperazines in Tet. Lett. 2011, 52(14): 1705-1708. doi:10.1016/j.tetlet.2011.02.011
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